Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Altered Peptide Ligands"”.
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Quantitative analysis of the T cell receptor signaling network in response to altered peptide ligands
… receptor, the T cell receptor, bind to multiple ligands resulting in different cell fates, based in part on the avidity of the ligand. To address the question of ligand affinity discrimination in T cells, several T cell lines, both mouse and human, were screened for their ability to exhibit …
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Antigen Recognition by an Alloreactive T Lymphocyte Clone
… ability of CTL 2C to recognize thiol-modified peptide variants is analyzed. A method for the synthesis and screening of thiol-modified peptides that are recognized by T cells is presented. Chapter three continues the peptide variant approach with examination of the ability of clone 2C and its …
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How TCR signal strength controls CTL polarisation for target killing
… T cell receptor (TCR). TCRs recognise a specific peptide chain loaded into a major-histocompatability complex, triggering signalling, inducing the CTL to attach and kill target cells. Key stages in this attack are the initial conjugation followed by polarisation and docking of the centrosome to …
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Modulation of the T cell response with MHC class I peptides and their analogues
… T cells specifically recognize donor MHC-derived peptides. This implies that it may be possible to develop antigen-specific strategies in order to modulate the alloimmune response by peptide analogues and specifically altered peptide ligands. The purpose of this study was to explore the potential …
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… or not, are CD4+ T cells that can recognize peptides presented on allogeneic (non-self) Major Histocompatibility Complex (MHC) molecules in addition to their conventional ligands, peptides presented on self MHC. It is an enigma as to how these alloreactive T cells can bind to allogeneic MHC …