Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Alpha1-antitrypsin"”.
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Characterization of Pleiotropic Activities of alpha1-Antitrypsin
… proteases released from inflammatory cells. alpha1-antitrypsin (AAT), an acute phase protein, is the prototypic member of the serpin super family and a major inhibitor of serine proteases such as neutrophil elastase. The clinical importance of AAT is highlighted in individuals with inherited …
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Alzheimer's disease and dementia with Lewy bodies: Special focus on the role of serpins
… investigated the role of three serpins, namely alpha1-antichymyotrypsin, alpha1-antitrypsin and neuroserpin, in the context of AD and DLB. We have shown that alpha1-antichymotrypsin: (i) renders the oligomer formation profile of incubated Abeta1-42, favouring dimer formation; (ii) under certain …
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Serpin polymers enforce molecular filtration in the endoplasmic reticulum
… failure of which can be toxic and cause disease. Alpha1-antitrypsin is the serine protease inhibitor (serpin) that is secreted mainly by hepatocytes and acts in lungs where its major function is to inhibit neutrophil elastase. Neuroserpin is a serine protease inhibitor expressed in the nervous …