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Showing 1 to 20 of 27 for “"Alpha-lactalbumin"”.
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COMPLEX FORMATION BY ALPHA-LACTALBUMIN AND POLYSACCHARIDE COPOLYMERS
Colloidal delivery systems, such as surfactant micelles, emulsions, liposomes, and nanoparticles, are widely used in food and pharmaceuticals to improve the dispersion of poorly-soluble ingredients or modify their bioaccessibility within the body. As a delivery system for medical- and …
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Structure and determinants of the alpha-lactalbumin molten globule
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Characterization of Lactational Performance in Transgenic Swine Overexpressing Alpha-Lactalbumin
Expression of the transgene was associated with increased milk production and increased piglet growth by transgenic reared piglets. Increased lactose synthesis in the may increase the contribution of lactose to the osmotic balance of colostrum, therefore increasing the water content and overall …
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Structural studies of the alpha-lactalbumin molten globule : implications for protein folding
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Structure-function analysis of HAMLET (human alpha-lactalbumin made lethal to tumor cells)
… is the prion protein, which changes from a mixed alpha-helical and beta-sheet conformation to the beta-sheet rich, disease causing iso-form. Protein folding is becoming recognised as a mechanism to generate beneficial functional diversity, however. One example is alpha-lactalbumin, which by …
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A dairy-based beverage development by alpha-lactalbumin/beta-lactoglobulin ratio adjustment for dysphagia patients
… entire time of consumption. Three ratios of α-lactalbumin (α-la)/β-lactoglobulin (β-lg) (3:8, 1:1 and 8:3) were used to prepare the milk systems. These ratio adjusted milk systems were either processed at 70, 80, and 90ºC for 30 min or at 25ºC, and cooled to 25 ± 1ºC. After the process was …
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CRISPR Cas9 targeted single nucleotide change at the (+15) loci of the alpha-lactalbumin gene
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Evaluation of risks associated with close environmental contact to swine that are transgenic for a bovine milk protein alpha-lactalbumin
… a mammary-specific transgene, bovine -lactalbumin, (B-LA) that results in increased milk production in sows. In this study, we wanted to determine whether B-LA is expressed in tissues of transgenic swine other than the lactating mammary gland and if the Tg DNA crosses into …
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Chemical and physical properties of bovine alpha-lactalbumin, beta-casein and genetically altered bovine beta-casein produced in the milk of transgenic mice
The genomic bovine $\alpha$-lactalbumin gene (1.7 kb) and the bovine $\beta$-casein gene (8.5 kb) linked to bovine $\alpha$-lactalbumin 5$\prime$ flanking region (2.0 kb) were expressed in two lines of transgenic mice, $\alpha$-114 and $\alpha\beta$ 34, respectively. Whey proteins, caseins, or skim …
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Ultrasonic Absorption in Solutions of Proteins and Peptides and in Suspensions of Liposomes
… aqueous solutions of myoglobin, apomyoglobin, (alpha)-lactalbumin, bacitracin, and the C and N-terminal CNBr cleavage fragments of myoglobin and equeous suspensions of large unilamellar lipid vesicles (LUV) of various compositions. Measurements were performed at temperatures between 20(DEGREES)C …
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Investigation of the kinetics of protein folding and the ensemble of conformations in non-native states of proteins by liquid NMR spectroscopy
… by studying three model proteins ubiquitin, [alpha]-lactalbumin and lysozyme in their folded and especially in their unfolded states. The proteins were chosen, because [alpha]-lactalbumin and lysozyme are two proteins with nearly identical fold but different function and ubiquitin is a very …
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Two-dimensional analysis and characterization of milk proteins
… and skim milk showed good separation between $\alpha$s1- and $\alpha$s2-caseins, and two separate bands in $kappa$-casein which are considered to be the genetic variants A and B. This procedure was also useful in the detection of bovine $\alpha$-lactalbumin in the milk of transgenic mice.
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Effects of gestation length and supplemental dietary fat on colostrum and milk composition in swine
… and milk. Qualitatively, the proportions of $\alpha$-lactalbumin and the novel cysteine-rich whey protein may have increased later after farrowing in the induced farrowing sows than in the naturally farrowing sows. An experiment was conducted to examine the effects of inducing farrowing on d …
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Chemical and physical changes resulting from UHT treatment of milk
… were used as an index to heat treatments. Alpha-lactalbumin was not denatured by the applied UHT treatments. The immunoglobulins were partly denatured, but a progressive increase in denaturation was not shown with increasing temperatures. Comparisons of these results with earlier work …
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In vitro milk protein secretion by explants of Holstein bull mammary tissue from two different genetic lines
… casein in media and homogenized tissue, alpha-lactalbumin in homogenized tissue, tri-chloro-acetic acid precipitable 3H-protein in media and homogenized tissue, and DNA content of cultured tissue. A subset of cultured explants from each bull was fixed and embedded for histological …
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Structure and Function of HAMLET: Epitopes, Membrane Interactions and Molecular Recognition
HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded human alpha-lactalbumin and oleic acid that kills many different types of tumor cells and shows therapeutic efficacy in animal models and clinical studies. This thesis aims to (1) elucidate the structure …
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Membrane Fouling In Cold Microfiltration Of Skim Milk: Mechanisms And Control
… in all foulant streams. In adsorption trial, [alpha]lactalbumin level in We was higher than in milk, which indicates an affinity of this protein for the membrane material. The serum proteins [alpha]-lactalbumin and bovine serum albumin (BSA) were found in a higher proportion in the "weakly …
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Artificial Induction of Lactation in Nonbreeder Dairy Cows
… cows exhibited an increase in serum alpha-lactalbumin concentrations 2 d prior to initiation of milking, reaching values of ~260 ng/ml. Mean days-to-first service was greatly reduced in cows induced into lactation compared to nontreated cows, while mean services per conception was …
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Influence of hormones on synthesis and secretion of milk proteins by mammary tissue from male and female cattle of beef and dairy breeds
… 3H-amino acids. Concentrations of non-labeled alpha-lactalbumin (Alac), 3H-Alac, and 3H-total protein (TP) were determined in media and in explant homogenates. Among cultures of bull mammary tissue, Angus explants secreted greater overall quantities of 3 H-TP and 3H-Alac than Holstein explants …
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Studies on improved integrated membrane-based chromatographic process for bioseparation
… Myoglobin (Mb), bovine serum albumin (BSA) and [alpha]-lactalbumin ([alpha]-LA) were used as model proteins in binary mixtures. Separation behaviors of binary protein mixtures were studied in devices using either an ultrafiltration (UF) membrane or a microfiltration (MF) membrane. Experimental …
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