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Showing 1 to 12 of 12 for “"Alpha Position"”.
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Guanidino-aryl substituted enol lactones: Selective and potent mechanism-based inhibitors of trypsin-like serine proteases
… tetrahydro-2-pyranone (4)) at the $\alpha$-position. The $\beta$-aryl substituted system included the 4-guanidino phenyl substituted protio and iodo enol lactones 4-(4-guanidinophenyl)-6-(methylidene) tetrahydro-2-pyranone (5) and 4-(4-guanidinophenyl)-6-(E)-iodomethylidene …
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Kinetics and mechanisms of oxidation of organic and inorganic substrates by transition metal oxo complexes
… CrO2+ involves a hydride abstraction from the [alpha]-position (primary and secondary 1,2-diols) or from the [beta]-position (pinacol). Reactions of phenols with CrO2+ produce the corresponding phenoxyl radicals in a rate-determining-step. The phenoxyl radicals are further oxidized by the …
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The synthesis and characterisation of Langmuir-Blodgett film forming TCNQ adducts.
… the short chain Z-beta-(l-butyl-4'-quinolinium)-alpha-cyano-4-styryldicyanomethanide (C[4]H[9](4)Q3CNQ) is a typical example. These zwitterionic D-pi-A materials (where D and A are electron donors and acceptors respectively) exhibit properties such as solvatochromism, molecular rectification and …
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Synthesis of Single Isomer Trisubstituted Olefins from beta-chloro-alpha-iodo-alpha, beta-Unsaturated Esters and Alkynyl Esters
… A unique olefin template such as (E)-beta-chloro-alpha-iodo-alpha,beta-unsaturated esters cross-couple with 9-alkyl-9-BBN to produce single isomer trisubstituted olefins using palladium-catalyzed Suzuki-Miyaura cross-coupling reaction. This methodology can be further expanded to introduce various …
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Novel genotoxins that target estrogen receptor- and androgen receptor- positive cancers : identification of DNA adducts, pharmacokinetics, and mechanism
… aniline mustard was linked to estradiol at the 7[alpha] position (E2-7[alpha]), and to target AR(+) prostate cancer, the aniline mustard was linked to estradien-3-one at the 11[beta] position (11[beta]). Competitive binding experiments show that E2-7[alpha] and 11[beta] compete well with the …
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Struktur-Wirkungsbeziehungen bei der enzymatischen Hydrolyse von Carbonsäureestern
… des sp2-hybridisierten Carbonylsauerstoffatoms (alpha–Position) zu finden sind. Dazu zählen insbesondere: Acylkettenlängen mit mehr als 4 Kohlenstoffatomen, iso-, sec- oder tert-Funktionen, aromatische Ringe mit polaren Gruppen wie 2-Hydroxy-Gruppen sowie trans-Doppelbindungen.
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Computational thermochemistry of hydrocarbons, oxygenates, cyclic alkanes, and furans
… literature values. Ketone C--H BDEs in the [alpha] position decrease by 6-9 kcal mol^{-1} with increasing substitution compared to normal alkane C--H BDEs. Group additivity (GA) and hydrogen-bond increment (HBI) values for these ketones are determined. Thermodynamic parameters for …
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Hepatic Apo E mRNA Levels in BALB/c and C57BL/6 Mice Fed Different Levels and Types of Oil
… analyses identified Apolipoprotein E, P450-15-$\alpha$-hydroxylase (Cyp 2a4) and seven unique genes. Apolipoprotein E is found on most lipoproteins and binds primarily to the LDL and Apo E receptors in the liver, thereby clearing lipoproteins from the plasma. Cyp 2a4 hydroxylates testosterone, …
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Hepatic Apo E mRNA levels in BALB/c and C57BL/6 mice fed different levels and types of oil
… analyses identified Apolipoprotein E, P450-15-$\alpha$-hydroxylase (Cyp 2a4) and seven unique genes. Apolipoprotein E is found on most lipoproteins and binds primarily to the LDL and Apo E receptors in the liver, thereby clearing lipoproteins from the plasma. Cyp 2a4 hydroxylates testosterone, …
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Supramolecular polymer additives to improve the crystallization behavior and optical properties of polybutylene terephthalate and polyamides
… are capable to efficiently nucleate the alpha form of PA6 even at concentrations below 200 ppm, with extremely high nucleation efficiencies of around 90 %. In addition, selected derivatives were found to distinctly improve the optical properties haze and clarity, as well as the laser …
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Synthesis and reactivities of titanocene-oxo complexes and rhodium-catalyzed oxidative amidation
… of amides bearing a quaternary carbon at the alpha position from sterically hindered aldehydes and alcohols. A variety of amines, both aliphatic and aromatic, were effective nucleophiles and generated the amide products in good to excellent yields. The aldehyde substrate scope was very limited …