Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Alpha Hemolysin"”.
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Nanopore Detector Feedback Control Using Cheminformatics Methods Integrated with Labview/Labwindows Tools
… RNA, or polypeptide) can be examined using an alpha-hemolysin channel detector. When a biopolymer is present in an alpha-hemolysin channel it can produce a highly structured ionic current blockade pattern, where the lifetimes at various sub-blockade levels reveal information about the kinetics …
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Analysis of Polyethylene Glycol in the α-Hemolysin Nanopore
… molecules of interest. These pores are usually α-hemolysin which is a toxin from Staphylococcus aureus or more recently nanoscale synthetic solid state pores. Now we are beginning to look at other molecules or proteins by sending them into the nanopores and measuring a characteristic partial …
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CHARACTERIZATION OF INDIVIDUAL CHARGED Au25(SG)18 CLUSTERS AND THEIR ENHANCEMENT OF SINGLE MOLECULE MASS SPECTROMETRY
… of polyethylene glycol (PEG) molecules within an alpha hemolysin (αHL) nanopore. The effect appears over a range of PEG sizes and ionic strengths. This increases the resolution of the peaks in the single molecule mass spectrometry (SMMS) current blockade distribution and suggests a means for …
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The development of a nanoscale Coulter counter for rapid genetic sequence recognition
… explored in this thesis, the biological toxin, alpha hemolysin, was implemented as "prototype" limiting aperture. With the practical knowledge gained from using a toxin channel, a general model for the nanopore as a low-noise sensor was developed. With this model, two broad goals were achieved. …
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Studies on the Role of Histone-like Proteins in Gene Regulation in Uropathogenic Escherichia coli Isolate 536
… mutation, resulting in increased expression of alpha-hemolysin, fimbriae and iron-uptake systems, as well as genes involved in stress adaptation. Furthermore, several other putative virulence factors were found to be part of the H-NS regulon. On the other hand, no effect of StpA alone was …
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Nanopores for detecting and sensing biological molecules
… alternative to traditional biological nanopores (Alpha-Hemolysin, MspA) since it provides a flexible nanopore with adaptability to DNA base types. Induced tension in MscL is shown to be different and distinguishable for each DNA base type. The speed of DNA translocation is also decreased by one …
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Bioelectronic in vitro models for monitoring intestinal host-pathogen interactions
… susceptibility of apical and basal membranes to alpha hemolysin toxin is made, in addition to the investigation of pathogenic extracellular vesicles interacting with the host cell membrane. These supported lipid bilayers interfaced with conducting polymer microelectrode arrays provide a …