Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Alpha Cells"”.
-
Regulation of glucagon secretion from pancreatic alpha cells
Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like …
-
Assessing Crosstalk Between Calcium and cAMP in Pancreatic Alpha Cells
… between insulin and glucagon. Pancreatic alpha cells release glucagon in response to a drop in blood sugar. Pancreatic alpha cells appear to be regulated through multiple signaling pathways. One potential method of regulation occurs from α-MSH or epinephrine stimulated production of the …
-
Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
… beta-cell insulin secretion and inappropriate alpha-cell glucagon secretion concomitant to peripheral insulin resistance. However, the mechanisms underlying dysregulation of pancreatic beta- and alpha-cells in type 2 diabetes require further investigation. Whereas triglycerides and saturated …
-
Manipulating proglucagon processing in the pancreatic alpha-cell for the treatment of diabetes
… Proglucagon is also expressed in the pancreatic alpha-cell; however, in this tissue PC2 is typically expressed instead of PC1/3, resulting in differential cleavage of proglucagon to yield glucagon as the major product. We hypothesized that expression of PC1/3 in the alpha-cell would induce GLP-1 …
-
Ceramide Accumulation in the Alpha Cell Drives Glucagon Secretion and Hyperglycemia
… described a lipid overload in pancreatic beta-cells that results in a lipid-induced dysfunction that ultimately leads to programmed cell death (1). More importantly, their later research in ZDF diabetic fatty rats showed an increase in serine palmitoyl transferase, the rate limiting enzyme in …
-
The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion
… tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose concentration, e.g. after a meal. The increased prevalence of T2D is associated with an increase in the prevalence of obesity, with obesity being the single …
-
Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
… (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins …
-
Caratterizzazione della funzione e del comportamento dell'alfa cellula pancreatica: analisi dei meccanismi fisiopatologici implicati nell'insorgenza del diabete
Le alfa cellule pancreatiche in corso di diabete producono glucagone in maniera inappropriata, senza risentire dell'effetto inibitorio dell'insulina. Lo scopo dello studio è stato quello di analizzare la funzionalità della cellula alfa in termini di secrezione di glucagone, dopo stimolo …
-
Basi molecolari della differente risposta delle cellule alpha e beta del pancreas di mammifero all apoptosi mediata da citochine: implicazioni patogenetiche nel Diabete Mellito
… cellule beta pancreatiche, mentre le cellule alpha risultano più resistenti ai loro effetti citotossici. Sebbene le pathways proapoptotiche innescate dalle citochine nelle beta cellule siano state ampiamente (anche se non completamente descritte), i meccanismi molecolari alla base della …
-
Beneficial effects of Cinnamomum burmannii in the treatment of diabetes mellitus
… to the distribution of pancreatic beta and alpha cells, the results show that cinnamon seems to improve the number of insulin and glucagon positive cells in diabetic rats. The human study data in non-‐diabetic subjects revealed that postprandial BGL were lower with cinnamon tea …
-
Tracing of Alpha-to-Beta Cell Transition Following Treatment with CHIR-Injected Human Multipotent Stromal Cell Secreted Proteins
… human bone marrow-derived multipotent stromal cells (BMMSCs), bioengineered via WNT pathway activation (CHIR+ conditioned media; CM), secrete factors that promote beta-cell recovery in streptozotocin (STZ) treated NOD/SCID mice. Here, we investigated whether this regeneration process involves …