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Showing 1 to 1 of 1 for “"Alpha 7 nicotinic acetylcholine receptor"”.
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Mild traumatic brain injury augments innate immune responses through neurokinin and cholinergic signaling
… mice did not. Using an FDA-approved neurokinin-1 receptor (NK1R) antagonist, aprepitant, we confirmed our previous findings that substance P (SP) is a key mediator of enhanced resistance to pneumonia. Blocking NK1R showed that mTBI-induced release of SP augments pulmonary neutrophil recruitment …