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Showing 1 to 13 of 13 for “"Allylic Oxidation"”.
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Synthesis, Structure, and Catalytic Activity of Bimetallic Rhodium Complexes in the Hydroformylation and Allylic Oxidation of Alkenes
… evaluated as potential catalysts towards the allylic oxidation of cyclohexene. At 0.1 mol% catalyst loading and 3 eq. of TBHP, a near quantitative substrate conversion was observed in the presence of a coordinating solvent, acetonitrile at 82 oC. Under such conditions, the heteroleptic …
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Synthesis and characterization of dirhodium(II) formamidinyl complexes: preliminary studies as catalyst precursors for the allylic oxidation of cyclohexene
… revealing a paddle-wheel type complex. Allylic oxidation reactions using the binuclear Rh complexes showed that these are active for cyclohexene conversion giving a range of products. Solvent coordination could have an effect on the catalytic behaviour of the complexes, with acetonitrile …
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Attempted Synthesis of a Photoreactive Geranylcysteine Derivative.
… with DHP/PPTs to generate <b>1</b> (98.1%). Allylic oxidation of <b>1</b> by using TBHP/SeO2 yielded <b>2</b> (31.5%). A modified oxidation increased the yield of <b>2</b> (34.4%). Treatment of <b>2</b> with BTC/pyridine afforded <b>3</b> (86.0%). Reaction of <b>3</b> with NaN3/DMF gave …
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Metal-free syn-dihydroxylation of alkenes using malonoyl peroxides
… nucleophiles is also discussed, and a novel allylic oxidation protocol using peroxide II is introduced. Chapter 4 discusses catalysis of the dihydroxylation reaction. Alcoholic hydrogen-bond donors with a pKa of 5-8 were found to be the most effective catalysts, achieving up to 4-fold rate …
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Synthetic Studies on Small Molecule Modulators of Src Homology 2 (SH2) Domain-Containing Inositol 5’-Phosphatase (SHIP)
… features of the new route include utilizing an allylic oxidation, ozonolysis, and lactonization for a more selective and controlled synthesis. In addition, this work has led to the synthesis of several new AQX-1125 analogs, providing information on structure activity relationships in this …
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Thioetherification and Etherification Utilizing Trichloroacetimidates Under Thermal Conditions & Progress Towards an Efficient Synthesis of AQX-1125
… been studied. The synthetic approach features an allylic oxidation of the C7 position and ozonolysis to generate key intermediates. Alternative routes have also been proposed and future investigations will aim to complete this project in the future.</p>
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Linear allylic C-H oxidation: methods and utility
… complex functional groups through the use of C-H oxidation methodologies has the potential to dramatically increase the efficiency of synthetic sequences with respect to resources, time and overall steps to key intermediates. This work describes methods that target complex intermediates to show …
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Improving synthetic efficiency through C—H activation
… of projects that develop and implement novel C—H oxidation reactions and strategies. Firstly, a mild and efficient oxidation strategy for the preparation of chiral polyols is presented and validated through an enantioselective synthesis of differentially protected L-galactose. This synthesis is …
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Studies towards the synthesis of the guaianolide and pseudoguaianolide skeleton
… of the alcohol configuration followed by an allylic oxidation 2 and finished by an oxidation of the primary alcohol 1. A proposal of the synthesis of dehydroleucodine is briefly explained. The final part is the experimental part. O O O H guaiane dehydroleucodine O O O H HO H H O HO H H O OH H …
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Design and Synthesis of Natural and Unnatural Macrocycles
… generation of the library is based on the tandem allylic oxidation/oxa-conjugate addition for the stereoselective synthesis of a 2,6-cis-tetrahydropyran ring. The incorporation of various building blocks and the utilization of diverse macrocyclization methods were carried out to rapidly increase …
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Development of palladium catalyzed intramolecular allylic C―H amination and oxidation towards pharmacological motifs
… has made significant developments in the area of allylic C―H oxidation and functionalization reactions. Using these methodologies, a variety of pharmacologically relevant small molecules have been synthesized in highly efficient sequences that minimized overall step counts as well as increasing …
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Exploration of Carbon-oxygen and Carbon-nitrogen Bond Formation Utilizing Trichloroacetimidates and Investigations of New Reactions Mediated By Oxoammonium Salts
… of these reagents, a new tandem elimination-oxidation process of tertiary alcohols has been discovered, synthesizing a protected allylic alcohol. Data suggests that the transformation first proceeds through elimination of the alcohol mediated by the oxoammonium salt. Then the allylic …