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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Allylic Amination"”.
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The Design and Application of Ion-paired Ligands to Address Selectivity Challenges in Transition Metal Catalysed Oxygen and Nitrogen Transfer Reactions
… C-H borylation, and rhodium-catalysed C-H amination and alkene aziridination. Chapter 2 explores the synthesis of novel ion-paired metalloporphyrins. Porphyrins are a privileged class of ligand that are challenging to render chiral. In this work, we executed the synthesis of novel porphyrin …
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EXPLORATION AND MECHANISTIC STUDY OF WEAKLY COORDINATING ANIONS UNDER THERMAL AND PHOTOCHEMICAL CONDITIONS FOR SELECTIVE TRANSFORMATIONS OF C-C MULTIPLE BONDS
… the conditions for a palladium catalyzed allylic amination reaction was undertaken. A systematic study on the roles of solvent, ligand loadings, and additives was conducted using High Throughput Experimentation, HPLC, and LCMS facilities at the GSK site.
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Part I: The Study Of 2-Aryl-1,3-Dithiane Derivatives As Pronucleophiles In Palladium-Catalyzed Allylic Alkylation And Propellylation Part Ii: Ligand-Free Palladium-Catalyzed Allylic Amintion Of Hydrazone Derivatives Part Iii: Synthesis Of Criegee Intermediate Precursors
… as pronucleophiles in palladium-catalyzed allylic alkylation and propellylation to access skeletally diverse aryl alkyl ketone cores. Allylic carbonate and [1.1.1]propellane electrophiles successfully couple with in situ generated 2-sodio-1,3-dithiane nucleophiles to afford the …
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Synthetic Studies in the Formation of Nitrogen Containing Compounds: From Simple Amines to Complex Natural Products
… previously developed palladium catalyzed tandem allylic amination/[2,3]-Stevens Rearrangement we were able to access unsaturated amino esters diastereoselectively. These could easily be converted to the desired azepane using a ruthenium catalyzed ring-closing metathesis reaction. Utilizing …
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C—H oxidation reactions: development and application
… the development of the first general, linear allylic C—H amination reaction, as well as applications of a biomimetic non-heme iron catalyst towards generating diverse oxidation products and exploring biological pathways. Linear allylic amines are a common motif found in many organic molecules; …
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Synthetic diversity in C-H activation: development of selective and efficient C-H functionalization reactions
… the development of novel C−H oxidation and amination reactions as new strategies for simplifying and diversifying synthetic sequences. First, harnessing the abundance of α-olefins as starting materials, palladium (II) catalysis is used to effect a divergent intramolecular allylic C−H …
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Development of palladium catalyzed intramolecular allylic C―H amination and oxidation towards pharmacological motifs
… has made significant developments in the area of allylic C―H oxidation and functionalization reactions. Using these methodologies, a variety of pharmacologically relevant small molecules have been synthesized in highly efficient sequences that minimized overall step counts as well as increasing …
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En-Reaktion von Nitrosoaren, Triazolindion und Singulettsauerstoff
Im Rahmen der vorliegenden Arbeit wurde der Mechanismus der En-Reaktion von Nitrosoaren (ArNO), Triazolindion (TAD) und Singulettsauerstoff (1O2) durch Bestimmung von kinetischen Isotopeneffekten, Regioselektivitäten und Diastereoselektivitäten mit ausgewählten, deuteriummarkierten Olefinsubstraten …