Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Allotransplantation"”.
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Overcoming skin rejection in composite tissue allotransplantation
… is not necessarily relevant to composite tissue allotransplantation. The second part of the thesis uses swine models to explore ways to overcome skin rejection while avoiding the toxicity of chronic systemic immunosuppression, through tolerance induction, and site specific therapy. Previous …
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Gene therapy studies of Adenoviral IL-10 transduced Dendritic cells in allotransplantation / by Toby Coates.
Studies the capacity of dendritic cells transduced with the immunosuppressive gene construct adenoviral interleukin-10 to inhibit alloimmune responses in both small and large animal transplantation models. There is promising in vitro evidence for gene therapy to modify dendritic cell function, …
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In-Vitro-Untersuchungen an mikroverkapseltem humanem Nebenschilddrüsengewebe : Vorarbeiten zur Therapie des permanenten Hypoparathyreoidismus mittels Allotransplantation ohne Immunsuppression
Die Allotransplantation der Epithelkörperchen stellt eine gute Alternative zur konservativen Therapie des permanenten Hypoparathyreoidismus dar; dennoch konnten die bisherigen langfristigen Ergebnisse von anderen Gruppen nicht reproduziert werden. Die Standardisierung der Transplantationsparameter …
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Porcine islet encapsulation for treatment of type-1 diabetes using precision particle fabrication method
… throughout the world. For the past few decades, allotransplantation of insulin-producing islets from the pancreas of deceased human donors has shown promising results in the restoration and sustenance of normoglycemia. Islet transplantation is a suitable procedure, especially for adolescents …
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GLP1R IS A T CELL NEGATIVE COSTIMULATORY MOLECULE
… When C57BL/6 mice received islet or cardiac allotransplantation from a fully mismatched BALB/c donors, an expansion of GLP1R+ CD4+/CD8+ cells occurred in the spleen and were found to infiltrate the graft at high percentage. Interestingly, the treatment with the GLP1R agonist Exenatide …
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The susceptibility of baboons to the novel immunosuppressant, FTY720
… problem. Since the drugs currently available for allotransplantation preferably target T -cells, and are therefore unlikely to be sufficient for xenotransplantation where there is a strong B-cell driven response, there is a need for new immunosuppressive agents. FTY720 (2 amino-2-(2-[ …
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Hypothermic Machine Perfusion of Composite Tissues
… preservation for Vascularized Composite Tissue Allotransplantation (VCA) has yet to be thoroughly investigated. This thesis explores the potential for hypothermic machine perfusion in prolonging limb graft viability in a swine forelimb amputation model. The experiment was designed with the right …
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Molecular Characterization and Inhibition of Antibodies Elicited Against Galactosyltransferase Knockout Pig Xenografts
… is both a viable supplement for, and bridge to, allotransplantation. Pigs are the favored organ donor because they: 1) breed and grow rapidly, 2) can be genetically modified, and 3) present few ethical concerns. However, due in part to their phylogenetic distance, several barriers must be …
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Histopathology of livers and native organs of recipients following genetically-engineered pig-to-baboon liver xenotransplantation
… therapeutic agents, bridging by a pig liver to allotransplantation may become a feasible clinical option. In project 2, blockade of both the CD40/CD154 and CD28/B7 pathways is required to prevent the baboon adaptive response to a pig artery patch graft. If the graft is taken from a CIITA-DN pig, …
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Experimentelle Nebenschilddrüsentransplantation : Untersuchungen zur Wirksamkeit einer temporären Immunsuppression auf die Transplantatfunktion
Erkrankungen der Nebenschilddrüsen stellen sich pathophysiologisch als Hyper- oder Hypoparathyreoidismus dar. Beim Hypoparathyreoidismus, der auf einer Nebenschilddrüsenunterfunktion basiert, wird zu wenig oder kein Parathormon gebildet. Infolgedessen kommt es pathophysiologisch zu einer …