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Showing 1 to 4 of 4 for “"Allosteric activators"”.
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Application of simulation methods for the identification of allosteric binding site in human glucokinase
Allosteric binding site, in generic terms, refers to a binding site distinct from the active site, where binding of an effector can enhance or decrease enzyme's activity. From a drug design point of view targeting allosteric binding sites can offer advantages in terms of selectivity, saturability, …
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Interrogation of the human glutamate dehydrogenase antenna to elucidate its role in allosteric regulation and disease
… organisms, but only GDH from animals is highly allosterically regulated by a wide array of metabolites. The importance of this regulation is made evident by hyperinsulinism/hyperammonemia syndrome (HI/HA), where mutations cause GDH hyperactivity. Since only allosterically regulated forms of the …
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Regulation of WASP in Actin Signaling: From Angstroms to Microns
… neutropenia. My graduate research was focused on allosteric regulation of WASP by an Enterohaemorrhagic E. coli (EHEC) effector EspFU. This study leads to novel mechanisms of WASP regulation and also sheds light on how cells conduct μm-scale assembly by orchestrating nm-scale proteins spatially …
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Designing Direct and Indirect Factor Xa Inhibitors
… tetrahydroisoquinoline (THIQ) nonsaccharide allosteric antithrombin activators was designed, synthesized, and biochemically evaluated to establish their structure–activity relationship (SAR). An N–arylacyl THIQ analog having carboxylate at position–3, two sulfate groups at positions–5 and –8 …