Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Allosteric Interactions"”.
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Allosteric Interactions in Coordination Cages
… Synthetic receptors that can mimic this allosteric binding behaviour extend the potential applications of host-guest chemistry to programmable molecular systems. Modulating the degree and magnitude of interaction between components within these systems enables the design of chemical …
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Cooperativity and communication in archaeal Cdc48·20S, an ancient proteolytic machine
… in ATP hydrolysis, protein unfolding, and allosteric interactions with the 20S and show how these features affect enzyme function. Experiments also show how the N domain controls D1-D2 interactions that govern ATP hydrolysis and substrate unfolding. Finally, I present experiments that take …
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Mobilização rápida de citocromo-oxidase por estimulação sensorial em córtex visual de gatos e primatas
… one or more genes of the enzyme' s subunits, of allosteric interactions with ATP, or of local redistribution of mitochondria.
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Mechanistic investigation of coordinated conformational changes in multisubunit ion channels and enzymes
… Coordinated conformational changes through allosteric interactions between subunits and/or between functional units can efficiently regulate protein activity. This dissertation describes investigations of coordinated conformational changes in two systems: the ATP-sensitive potassium (KATP) …
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Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
… structure in all protein kinases, or through allosteric binding of one of its partner proteins, Tpx2, and each of these mechanisms regulates separate functions of the kinase in cells. Furthermore, overexpression patterns of Aurora kinases have been observed in a number of human cancers that …
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MOLECULAR MECHANISMS OF ACTIN FILAMENT ASSEMBLY AND TURNOVER
… an actin monomer, and being expelled by the allosteric interactions of a new Lmod2 subunit. Finally, the synergistic depolymerization by cofilin, cyclase-associated protein (CAP), and capping protein are revealed by twelve structures. Cofilin binds cooperatively along an actin filament, …
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From ribosomal rotation to autism and cancer
… networks of near-, medium-, and long-range allosteric interactions involved in coordinating intersubunit rotation. These allosteric pathways map from L10 in the core of the large subunit and propagate outward through both subunits, linking all of the functional centers of the ribosome. …
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Enhanced Architectural and Structural Regulation Using Controlled Free Radical Polymerization Techniques; Supramolecular Assemblies: Pseudorotaxanes and Polypseudorotaxanes
… association, a likely result of increased p -p interactions among host and guest species. The association between a bicyclic macrocycle and dimethyl paraquat was also investigated. Not surprisingly, binding of paraquat by the bicyclic was much stronger than the binding found in analogous …