Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Allorecognition"”.
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CD4 T cell allorecognition pathways in acute and chronic allograft rejection
… rejection. 2) Direct-pathway CD4 T cell allorecognition is restricted to the immediate post transplantation period. Donor APCs are the major source of MHC class II for direct-pathway priming, and these are cleared rapidly by both innate and adaptive responses of the recipient, effectively …
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Germinal centre autoantibody responses following heart transplantation
… responses were initiated upon graft-versus-host allorecognition of recipient B cells by donor CD4 T cells transferred within the heart allograft. Rejected allografts displayed features of chronic humoral vascular rejection, with rejection mediated by long-lasting germinal centre (GC) responses, …
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Substratum Interactions Modulate the Interplay between Endothelial Cell Phenotype, Function, and Immune Recognition
… and function and how these differences affect allorecognition in a model of cell transplantation. Investigation of EC state was carried out using RNA sequencing and flow cytometry while assessment of the allogeneic response included measurements of immune cell cytotoxic ability, T cell …
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Characterizing the Immunogenicity of Islet-like Cells derived from HLA-edited Human Pluripotent Stem Cells
… functionality, I find that CD8+ and CD4+ T cell allorecognition requires the presence of cell-surface HLA. Importantly, islet-like cells generated from HLA-edited human pluripotent stem cells demonstrate the potential to evade antibody-mediated rejection in vitro and T cell-mediated rejection in …
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Tumor-induced macrophage and T cell dysfunction
… and these cells significantly suppressed T-cell allorecognition and autorecognition. TBH CD8⁺ T-cell suppression was mediated partly through dysregulation of IFN-y, IL-4, and PGE₂ production. TBH CD4⁺ T cells produced less GM-CSF than NH CD4⁺ T cells, and GM-CSF dysregulation was linked partly to …
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Modulation of the T cell response with MHC class I peptides and their analogues
… that the specific suppression of indirect allorecognition can be achieved by using peptide analogues of the dominant allopeptide.
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… MHC composition all contribute significantly to allorecognition.</p>
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Untersuchungen zum immunbiologischen Effekt spender-spezifischer MHC-Klasse-II-Peptide nach experimenteller Nieren- und Dünndarmtransplantation
Heutige Therapieformen können dem Anspruch einer spezifischen Unterdrückung der Immunreaktion gegen das Transplantat bislang nicht gerecht werden. Langfristiges Ziel muss es sein, ausschließlich die T-Lymphozyten zu unterdrücken, die an der Transplantatabstoßung beteiligt sind. Dazu ist es …