Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Allopregnanolone."”.
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The Effects of Allopregnanolone on Feeding: A Behavioural Investigation
Allopregnanolone (5α-pregnan-3α-ol-20-one), a neurosteroid, has been shown to produce hyperphagia in rodents. The effects of allopregnanolone on appetitive and Consummatory behaviors associated with feeding were examined. Allopregnanolone had no effect on consummatory behaviors, as measured by the …
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Age-related differences in ethanol withdrawal, withdrawal-induced anxiety, cognition, and response to allopregnanolone.
… we investigated the effects of an acute dose of allopregnanolone on spatial memory in aged rats. In accordance with previous research, adult animals showed impaired performance when treated with allopregnanolone. However, the results for the aged animals were not statistically significant. …
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Il trattamento neonatale con estradiolo modifica l'espressione e la funzione dei recettori GABAA e la sensibilità allo stress nel ratto adulto
… and plasma concentrations of its metabolite, allopregnanolone. Given that allopregnanolone is a potent positive modulator of GABAA receptor (GABAAR) expression and function, it has been evaluated whether neonatal estradiol treatment affects, during adulthood, GABAAR expression and function in …
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Neonatal exposure to estradiol in female rats influences neuroactive steroid concentrations and behaviour in the adult rat
… plasma concentrations of the neuroactive steroid allopregnanolone, general behaviours and behavioral sensitivity to benzodiazepines. Neonatal administration of EB induces a dramatic reduction in the cerebrocortical and plasma levels of allopregnanolone and progesterone that were apparent in both …
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Pamam dendrimer-based therapeutic and diagnostic nanodevices
… in PBS buffers at pH 7.4 for EM and pH 2.1 for allopregnanolone were evaluated by reverse phase HPLC (RP-HPLC) analysis. EM released quite fast, about 90% of the drug was released within 10 hours and completed within 20 hours, while allopregnanolone released in slower manner, about 90% of the …
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Recettori purinergici ionotropi e i loro ruoli nella neuroinfiammazione mediata dalla microglia
… del colesterolo, come testosterone butirrato, allopregnanolone, 17-estradiolo e 25-idrossicolesterolo. Presi insieme, i dati qui riportati forniscono nuove informazioni sulla modulazione della corrente purinergica nelle cellule della microglia, suggerendo nuove interazioni nelle vie di …
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Regulation of Expression of 5 Alpha-Reductase Type 1 in Mouse Leydig Cells
… conditions and mmetabolized progesterone to allopregnanolone, but MA-10 cells yielded additional products. Treatment of MLTC-1 cells with forskolin or human chorionic gonadotropin dramatically decreased 5a-reductase type 1 activity in the cells after 1 hour. Future experiments will address …
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The long-term effects of reproductive experience on the neurobiology of anxiety and its treatment: a cross species approach in female rats and women
… a lower peak and blunted decline in circulating allopregnanolone (an anxiolytic neurosteroid implicated in cyclic changes in anxiety and benzodiazepine sensitivity) levels across the estrous cycle. Finally, Chapter 7 translated the rat findings of Chapter 2 to humans by showing that self-reported …
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La clozapine et les neurostéroïdes dans la modulation de comportements associés au suicide dans un modèle murin de schizophrénie
… alters central neurosteroid (NS) levels, such as allopregnanolone. The present work was to evaluate if the effectiveness of clozapine for reducing the risk of recurrent suicidal behaviors is mediated through NS modulation. Finasteride, a 5α- reductase inhibitor was injected alone or before …
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Neurosteroids: endogenous analgesics?
… reduced with development. The neurosteroids allopregnanolone and ganaxolone were significantly more effective in neurones from the older mice. In contrast, ?-cyclodextrin had significantly less effect in neurones from the older mice. In mature diabetic mice (ob/ob mice), the endogenous …
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Alterazioni indotte dall'isolamento sociale sulla regolazione a feedback negativo dell'asse ipotalamo-ipofisi-surrene
… δ GABAA receptor subunits in basal condition and allopregnanolone (AP) levels after stress exposure. Socially isolated rats exposed to foot-shock stress showed a marked increased in plasma corticosterone levels which were still significantly high 7 hours later, while in group-housed animals plasma …