Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Alloimmune"”.
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Molecular Characterization of the Human Alloimmune Response
… cloning. Nevertheless, we failed to detect an alloimmune response in this T cell line stimulated with HLA-A2 transfected APCs three times over a 21- day culture period. These results suggest that either the frequency of alloreactive T cells was below the limit of detection by these methods or …
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Molecular Characterization of the Human Alloimmune Response
… cloning. Nevertheless, we failed to detect an alloimmune response in this T cell line stimulated with HLA-A2 transfected APCs three times over a 21- day culture period. These results suggest that either the frequency of alloreactive T cells was below the limit of detection by these methods or …
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Humoral alloimmunity in cardiac allograft rejection
… impact of the different phases of the humoral alloimmune response (follicular or germinal centre) on graft rejection.
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GLP1R IS A T CELL NEGATIVE COSTIMULATORY MOLECULE
… and the role of its signalling during alloimmune response. Our data showed that, a subset of naïve CD4 and CD8 lymphocytes expresses GLP1R in humans and mice. When C57BL/6 mice received islet or cardiac allotransplantation from a fully mismatched BALB/c donors, an expansion of GLP1R+ …
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Gene therapy studies of Adenoviral IL-10 transduced Dendritic cells in allotransplantation / by Toby Coates.
… construct adenoviral interleukin-10 to inhibit alloimmune responses in both small and large animal transplantation models. There is promising in vitro evidence for gene therapy to modify dendritic cell function, which in small animal models can modify skin graft rejection. In large animals, …
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THE DEVELOPMENT OF SELECTIVE PHOTOSENSITIZERS TO TARGET PATHOGENIC T CELLS AND PREVENT GRAFT-VERSUS-HOST DISEASE
… immunologic disorders, including autoimmune and alloimmune diseases. In hematopoietic stem cell transplantation, acute graft-versus-host-disease (GVHD) is caused by an attack on the recipient's tissues from donor allogeneic T cells. In cutaneous T cell lymphoma (CTCL), malignant T cells migrate …
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CD4 T cell allorecognition pathways in acute and chronic allograft rejection
… to chronic rejection. It is evident that the alloimmune response remains incompletely characterised. Crucially, despite description several decades ago, the precise contribution that the direct (recognition of intact allogeneic MHC) and indirect (recognition of self-MHC restricted allopeptide) …
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Modulation of the T cell response with MHC class I peptides and their analogues
… leads to the activation of the recipient’s alloimmune response as a major determinant of transplant outcome. T cell recognition of foreign MHC molecules plays a key role in initiating and sustaining allograft rejection. To prevent the risk of rejection, patients are given immunosuppressive …
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Structural and electrostatic analysis of HLA B cell epitopes: Inferences on immunogenicity and prediction of humoral alloresponses
… agents, injury secondary to the alloimmune response principally directed against mismatched HLA antigens, remains a significant cause of renal transplant dysfunction and loss. One of the principal ways to limit the detrimental effect of immune alloreactivity towards the graft is …
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Role of IL-17A and Acaid in the Maintenance of Corneal Immune Privilege
… T regulatory cells (Tregs) that suppress alloimmune responses directed against the corneal transplant. Finally, by comparing and contrasting the cellular and cytokine requirements of corneal immune privilege and ACAID, these investigations unveil the independent mechanisms operating in the …
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Investigating the antibody-independent functions of B lymphocytes
… and this can inhibit deleterious autoimmune and alloimmune responses in murine models. Here I investigated whether B cells may play a pathogenic role in the sterile inflammation associated with acute kidney injury (AKI), coordinating a systemic response in which neutrophils and inflammatory …
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Complement activation and effector pathways in ischaemia reperfusion injury and at the interface with adaptive immunity
… the transplant procedure has an impact on the alloimmune response.
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… may also play a protective role by regulating alloimmune responses promoting transplant tolerance. B-Lymphocyte Stimulator (BLyS) is a cytokine that promotes B cell activation and survival. We performed the first randomized controlled trial using belimumab as early maintenance immunosuppression …
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
… T cells on the development of humoral auto- and alloimmune responses in a prospective cohort of primary lung transplant recipients (n=21). The development of autoantibody and, in particular, the specificity of target autoantigens was also evaluated in a lung transplant patients with either …