Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Allografts"”.
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The role of purified antibodies and antibody fragments in the enhancement and the acute destruction of mouse allografts
Contains fulltext : mmubn000001_02657666x.pdf (Publisher’s version ) (Open Access)
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The Impact of Ventricular Assist Device Prior to Transplantation on Morphological Parameters in Cardiac Allografts /// Въздействие на вентрикуларните помощни устройства преди трансплантация върху морфологичните параметри при сърдечните алографи
… endomyocardial biopsies (EMBs) of cardiac allografts. Methods: We evaluated all consecutive EMBs of cardiac allografts from 254 patients taken between 01/2011 and 12/2012.With regard to pre-transplant MCS treatment, patients were divided into two groups (MCS group n=82 patients, non-MCS …
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Evaluation of tumour perfusion and fibrosis in mouse models of pancreatic ductal adenocarcinoma, using MRI
… mouse models of PDA: spontaneous KPC tumours, allografts initiated by transplantation of pancreatic tumour cells derived from a KPC tumour, and allografts initiated by co-transplantation of these cells with pancreatic stellate cells (fibrotic allografts). Using DCE-MRI and MTI we showed that …
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Destruction of Corneal Nerves Promotes Corneal Allograft Rejection
… contributes to the 90% success rate of corneal allografts without the need for histocompatibility matching and use of systemic immunosuppressive therapy. However, when one or more parameters that contribute to immune privilege are broken, the cornel allograft becomes vulnerable to the immune …
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Regulatory mechanisms in transplantation tolerance: the induction of tolerance by adoptive transfer in MHC-inbred miniature swine
… the long term survival of kidney allografts have remained the same due to unchanged rate of chronic rejection. Even with acceptance of renal allografts, patients require lifelong use of immunosuppressants. The induction of transplantation tolerance may allow for patients to receive …
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Role of Allergic Conjunctivitis in Inducing Corneal Transplant Rejection
Corneal allografts are the most commonly transplanted solid organs in humans and have a success rate of over 90%. This low incidence of graft rejection is largely due to the unique properties of the eye that decrease the likelihood of mounting an immune response, a phenomenon called "immune …
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Humoral alloimmunity in cardiac allograft rejection
… improvement in long-term survival of solid allografts. This thesis presents the initial characterisation of alloantibody mediated rejection in a murine heart transplant model, with particular focus on the impact of the different phases of the humoral alloimmune response (follicular or …
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Germinal centre autoantibody responses following heart transplantation
… transferred within the heart allograft. Rejected allografts displayed features of chronic humoral vascular rejection, with rejection mediated by long-lasting germinal centre (GC) responses, whose maintenance was dependent upon additional, cognate help from recipient T follicular helper (TFH) …
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Application of a Periosteum-bone Allograft for Healing of Segmental Bone Defects
Whole bone allografts or autografts are commonly applied surgically to repair approximately 2.2 million segmental bone defects annually caused by trauma or bone tumor resection worldwide.[1] However, about 15-40% of these cases result in unsuccessful healing because of a persistent gap or nonunion …
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Electrospun Blends of Polydioxanone and Fibrinogen for Urological Applications
… cannot be satisfied by autograft and allografts alone. The purpose of this study was to investigate the feasibility of electrospinning a blend of polydioxanone and fibrinogen to produce an engineered tissue scaffold. Fiber diameter and pore size of blends were characterized, as well as …
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Osteochondral allograft preservation in a serum-free chemically-defined media
… the tissue have been developed. Osteochondral allografts (OCAs) allow the transplantation of whole cartilage tissue into a defect with viable cells, or chondrocytes that will maintain the cartilage matrix. Fresh OCAs have demonstrated greater than 75% clinical success in the treatment of …
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In vitro and in vivo assessments of PCL-TCP composites for bone tissue engineering
… site morbidity and is limited by defect size. Allografts and xenografts are not as popular due to the increased risk of disease transmission, high cost and graft rejection. Shortcomings of current bone grafts motivate researchers to look into polymer composites for better substitutes. PCL-TCP …
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Role of IL-17A and Acaid in the Maintenance of Corneal Immune Privilege
… allows first time recipients of corneal allografts to enjoy a 90% success rate in the absence of systemic immunosuppressive drugs and without prior tissue typing. The myriad of immunoregulatory components that conspire to maintain the immune privilege of the cornea can be assigned to one …
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The performance of cross-linked acellular arterial scaffolds as vascular grafts; pre-clinical testing in direct and isolation loop circulatory models
… available, synthetic grafts perform poorly and allografts and xenografts degenerate, dilate and calcify after implantation. We hypothesized that chemical stabilization of acellular xenogenic arteries would generate off-the-shelf grafts resistant to thrombosis, dilatation and calcification. To …
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Uterus transplantation: an experimental study in the rat model
… group. Low numbers of T-cells were seen in most allografts treated with tacrolimus. Levels of the cytokines IL-1 and IP-10 were increased in the non-treated transplanted group and levels of the implantation marker galectin-1 were normalized after tacrolimus treatment. Different sites of diagnosis …
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An alginate hydrogel matrix for the localised delivery of a fibroblast/ keratinocyte co-culture to expedite wound healing
… alternative skin replacements to autografts, allografts and xenografts. In this thesis a bi-layer skin graft was developed by encapsulation of fibroblasts in calcium-alginate hydrogel and culture of keratinocytes on the surface. Initially, the use of 5% and 2% w/v alginate hydrogels were …
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Polypyrrole : an interactive substrate for bone regeneration
… rely on autografts (bone from a donor site) and allografts (bone from human cadaver). However, these methods are plagued with disadvantages. There is a clear and urgent need to provide alternatives for regenerating and repairing bone. Bone is known to be one of the many connective tissues in the …
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Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins
… availability and surgical morbidity. The use of allografts obtained from donors is also not desirable due to the risks of disease transmission and the costs of maintaining bone banks. The ideal solution would be to regenerate native bone to fill the defects. A group of potent growth factors known …
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Investigating the Role of the Lysine-Specific Demethylase 4C in Pancreatic Ductal Adenocarcinoma
… survival of orthotopically implanted murine PDAC allografts. Transcriptomic and proteomics analyses revealed that loss of KDM4C in both human and murine PDAC cell lines was associated with the reduction of activated phospho-ERK, a pivotal effector downstream of mutant RAS. Using proximity …
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The susceptibility of baboons to the novel immunosuppressant, FTY720
… rejection still remains, and unresponsiveness to allografts has never been induced by these immunosuppressive agents. More importantly, the presence of adverse side effects including immunological complications and drug toxicity e.g. nephrotoxicity, remains a serious problem. Since the drugs …
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