Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"Allodynia"”.
-
Synergistic inhibition of cyclooxygenases and monoacylglycerol lipase in neuropathic pain
… by altered nerve function that often presents as allodynia, which is the painful perception of typically non-noxious stimuli. Neuropathic pain is commonly treated with GABA analogues, steroids, or non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit one or more cyclooxygenase (COX) …
-
Tnf Signaling During Tissue Damage-Induced Nociceptive Sensitization In Drosophila
… in results in epidermal apoptosis and thermal allodynia. TNF/Eiger is produced from dying epidermal cells and acts its receptor in nociceptive sensory neurons to induce thermal allodynia. Inhibition of TNF signaling results in attenuation of nociceptive sensitization whereas epidermal apoptosis …
-
THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE
… a polyneuropathy of paresthesia, hyperalgesia, allodynia, and numbness, primarily felt in the hands and feet. With no current FDA-approved medications to treat the entirety of CIPN’s symptoms, it is essential to find solutions for this condition. Veering away from classic prescription …
-
Estrogen Signaling in Trigeminal Nociception
… to stimulation of the masseter (V3, primary allodynia) and whisker pad (V2, secondary allodynia) using graded monofilaments. Estrogen treatment in the presence of inflammation increased withdrawal response to stimulation of either masseter or whisker pad compared to inflammation alone, …
-
Development of a mouse model for the study of osteoarthritis pain
… weight bearing, mechanical hyperalgesia, cold allodynia, mechanical allodynia and vocalisation in response to knee compression for 12 weeks post-surgery. No significant weight bearing deficits were observed during the course of the study. Significant mechanical allodynia was present in the …
-
Cannabinoid Modulation Of Cisplatin Induced Neuropathy
… effective in attenuating or preventing tactile allodynia associated with cisplatin-administration. Mice (c57bl/6) were given eight doses of 2.3 mg/kg cisplatin or saline solution ip every second day to induce tactile allodynia (ringers on alternate days). Tactile responses to hind-paws were …
-
Two methods of biomarker discovery: applications in neuropathic pain and pharmacotherapy.
… resulting in ‘dose-dependent’ behavioural allodynia. Allodynia was correlated with microglial activation marker expression in the ipsilateral lumbar dorsal horn of the spinal cord, suggesting that changes in behaviour are associated with disease mechanisms. A literature review of the …
-
Codeine, heightened pain sensitivity and medication overuse headache: a neuroimmune hypothesis and novel treatment strategy.
… headache and opioid-induced hyperalgesia and allodynia. Despite the clinical impact of medication overuse headache the pathophysiology behind this disorder remains unclear and mechanism-based treatments are lacking. Although most acute headache treatments are alleged to cause medication …
-
Impact of environmental and genetic factors on pain sensitivity and chronic pain development
… the oxaliplatin rat model. Rats develop dynamic allodynia at the incision site, which peaked on post-surgical day two and recovered by day seven. This was accompanied by a change in skin structure. Immunohistochemical investigation revealed the development of putative dermal papillae within 24 …
-
Functional and molecular approaches to study mu and delta opioid receptor hetero-oligomerization in a model of neuropathic pain
… from environmental stimuli, and mechanical allodynia in this paw. Behavioural studies reported that acute injection of DOR- selective agonists that bind M/DOR produced enhanced thermal antinociception and reversed mechanical allodynia in NP rats. DOR agonists that have low binding affinity …
-
Exploring the use of manual therapy as an adjunctive therapy to 'care as usual' on outcomes in chronic migraine.
… presence of higher baseline levels of cutaneous allodynia, negative coping and emotional distress indicated a greater benefit from the combined MT/ 'care as usual' intervention than 'care as usual' alone. This was the first MT-CM RCT to take place in a UK tertiary NHS headache clinic and …
-
A Pre-Clinical Assessment of Minocycline For Treatment of Chronic Neuropathic Pain After Spinal Cord Injury
… significant reduction in below-level mechanical allodynia and above- level hyperalgesia while on their treatment regimen. After a ten-day washout period of minocycline, the animals continued to demonstrate a significant reduction in below-level mechanical allodynia and above-level hyperalgesia. …
-
Anti-inflammatory and joint-protective effects of blueberries in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis
… after euthanasia for analysis. Mechanical allodynia and joint width were assessed at four timepoint throughout the study to evaluate changes in pain behaviors and edema. Results from the in vitro study showed TNFα increased cell proliferation by ~ 19% compared to the non-stimulated control. …
-
Evaluating the Structural and Functional Consequences of Traumatic Joint Injury and their Relation to NF-κB in a Non-Invasive Model of Post-traumatic Osteoarthritis
… behavior including the acute presentation of allodynia, hyperalgesia, and transient alterations to weight bearing and ambulation/gait. Persistent unilateral allodynia was observed up to 4 months following injury. Furthermore, early NF-κB activation following injury was correlated with the …
-
Effect of cannabinoids on pain-stimulated and pain-depressed behavior in rats
… noxious stimulus to stimulate mechanical allodynia (pain-stimulated behavior) or depress ICSS (pain-depressed behavior). Cannabinoids tested in the assays of acid-stimulated stretching and acid-depressed ICSS included: mixed CB1R/CB2R agonists THC and CP55940, drugs that modulate levels of …
-
Voluntary Exercise and Neurotrophin Signaling Affect the Development and Presentation of Painful Neuropathy
… stinging sensations, as well as hyperalgesia and allodynia. Research suggests that altered neurotrophism may account for the development and maintenance of PDN, resulting in a dying back of peripheral neurons, leading to pain. Furthermore, patients suffering from painful diabetic neuropathy (PDN) …
-
Regulation of Neuropeptide Y, Vasoactive Intestinal Polypeptide, and Their Receptors in Trigeminal Ganglion Neurons and Glia in Response to Adjuvant-Induced Inflammation
… into the joint of rats, mimicking mechanical allodynia seen in TMJ disorder. Trigeminal ganglia were dissected after 1, 3, and 5 days after CFA-treatment. NPY expression was observed in Day 1 and Day 5 tissues, with localization to glial cells, and to both neurons and glial cells, …
-
Damage-Induced Inflammation and Nociceptive Hypersensitivity In Drosophila Larvae
… found that larvae have a lowered pain threshold (allodynia) and an exaggerated response to noxious stimuli (hyperalgesia) following UV damage. We screened for genes required for hypersensitivity in pain receptors (nociceptors), and discovered a number of novel mediators that have well conserved …
-
Secondary Traumatic Stress Promotes Peripheral Trigeminal Nociceptor Sensitization
… that during an attack, leads to hyperalgesia and allodynia. Sensitization and activation of peripheral trigeminal neurons that provide sensory innervation to most of the head and face is implicated in migraine pathology. The most commonly cited risk factor for migraine is stress, and in …
-
Neuroprotective Potential of a Lanosteryl Triterpene from Protorhus longifolia Stem Bark (Benrh.) Engl in high fat diet fed and STZ -induced diabetic neuropathy in rats
… assess the responses of the rats to cold and hot allodynia following 28 days of treatment with the respective drugs. On the last day of the experimental period, all rats were euthanized and blood (serum), sciatic nerve and brain tissues were collected for analysis of biochemical parameters. v The …
Page 1 of 3