Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Alloantibody"”.
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Characterisation of Alloantibody-Human Leukocyte Antigen Interactions to Improve Immunological Risk Assessment in Solid Organ Transplantation
… (BLI) was used for real-time quantification of alloantibody-HLA kinetics. Outputs from each immunoassay were found to be dependent on antibody concentration, [Ab], where the degree of CDC was proportional to the antibody’s affinity, KD. The strongest affinity for each antibody was measured with …
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Humoral alloimmunity in cardiac allograft rejection
… thesis presents the initial characterisation of alloantibody mediated rejection in a murine heart transplant model, with particular focus on the impact of the different phases of the humoral alloimmune response (follicular or germinal centre) on graft rejection.
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Structural and electrostatic analysis of HLA B cell epitopes: Inferences on immunogenicity and prediction of humoral alloresponses
… of EMS-3D to predict the development of de novo alloantibody responses was assessed in a cohort of patients who received a standardised immunisation and had their antibody profile characterised using Luminex single-antigen beads. This analysis validated EMS-3D as a valuable predictor of the …
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CD4 T cell allorecognition pathways in acute and chronic allograft rejection
… long-lived, and can provide help for generating alloantibody against different MHC alloantigens. 4) In response to continual presentation of target epitope indirect-pathway CD4 T cell responses against parenchymal expressed alloantigen are long-lived. The continual division of these cells results …
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Investigating the role of HLA class I derived peptide in alloreactivity.
… further insight into the complex nature of alloantibody binding, and aides the understanding of this process.
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The role of B cells in the amplification and in the regulation of transplant rejection.
… graft rejection through the production of alloantibody and their capacity<br/>to efficiently present alloantigens. However, recent clinical trials with B cell<br/>depletion have suggested that B cells contribute to the regulation of immune<br/>responses to grafts. In addition the evidence …