Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Allicin"”.
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Synthesis and inclusion studies of stable allicin mimics as novel antimicrobial agents
Allicin, a known constituent of garlic, is a potent but unstable antimicrobial agent. Consideration of the underlying features responsible for allicin’s activity, as well as its instability, prompted an investigation into substituted S-aryl alkylthiosulfinates as a class of potential allicin mimics …
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The immunomodulatory effects of the garlic organosulfur compounds allicin and Z-ajoene in an in vitro murine model of LPS-induced inflammation
… by gene and protein arrays. Results showed that allicin had a more pronounced upregulatory effect on LPS-induced gene expression 4 h post-LPS treatment. In contrast, Z-ajoene generally had mild downregulatory effects on the expression of LPS-induced genes. Conversely, Z-ajoene had pronounced …
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Flavin-dependent Enzymes in Natural Product Biosynthesis
… enzymes perform heteroatom oxidation as part of allicin or fosfazinomycin biosynthesis respectively. AsFMO was predicted to oxidize S-allyl-L-cysteine (SAC) to alliin in allicin biosynthesis. Surprisingly, AsFMO exhibited negligible activity with SAC, and instead was highly active with allyl …
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Reversed-Phase HPLC Determination of Alliin in Diverse Varieties of Fresh Garlic and Commercial Garlic Products.
… cloves are crushed, cut, or chewed to produce allicin, an unstable thiosulfinate that is the main biologically active component of fresh crushed garlic. Biological functions and health benefits of garlic include reduction of cancer risk in humans, improving immune system, and anti-microbial, …
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Modes of action of antimicrobial garlic derivatives
… of preparing G. P for use was developed and the allicin content (from alliin) determined by both pyruvate and ammonia assays to be approximately I 1.00mg/ g was shown to be comparable to published data. 2) Quantitative and qualitative methods for determining the sulphide and thiosulphinate …
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Distribution and function of TRP ion channels in primary sensory neurons
… a number of organosulphur compounds, including allicin and diallyl disulfide (DADS), some of which may contribute to its pungent and vasodilator properties. Our results show that raw garlic extract, allicin and DADS activate TRPA1 ion channels on primary sensory neurons in culture and nerve …
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Investigating the Influence of Fresh and Aged Garlic Extracts on the Biosynthesis of Trimethylamine N-Oxide
… of bioactive garlic phytochemical allicin has recently been suggested to reduce the formation of TMAO precursor molecule trimethylamine (TMA) from L-carnitine through impact on the intestinal bacteria, thereby limiting the formation of TMAO by the host. Purpose: The objective of …
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Mechanistic Studies of Flavin-Dependent Monooxygenases Involved in Bacterial Defense and Plant Metabolism
… TvMAS1 to primarily have a physiological role in allicin, not marasmin biosynthesis. Lastly, we characterized the auxin-producing FMO YUC10 from Arabidopsis thaliana and showed the enzyme to only have steady-state activity with aromatic α-keto acids indole-3-pyruvic acid (IPA) and phenylpyruvic …
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An Activity-Based Proteomics Approach for Identifying Ajoene's S-thiolation Protein Targets in Blood and Cancer Cells
… findings on the cancer-cell protein targets of allicin from crushed garlic, by identifying proteins regulating apoptotic and antiproliferative signalling pathways. These findings support the hypothesis that the anticancer activity of ajoene is due to its S-thioallylation of proteins essential to …