Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Allergic Inflammation"”.
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… trigeminal sinonasal neurons in the context of allergic disease remain largely unexplored and unclear. This study investigated the impact of intranasal administration of house dust mite or fungal allergens on these cells and sought to understand the mechanisms underpinning the allergic response. …
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Development of screening assays to test novel integrin antagonists in allergic inflammation
… of action of integrin-mediated levocabastine antiallergic action. Results: This thesis provides evidence that adopting scintillation proximity assay (SPA) levocabastine (IC50=406 mM), but not the first-generation antihistamine chlorpheniramine, displaces [125I]fibronectin (FN) binding to human …
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The role of autophagy in allergic inflammation: a new target for severe asthma
… Inhibition of autophagy improved AHR and airway inflammation 17 5. Knockdown of Atg 5 attenuates AHR and airway inflammation 20 6. Positive correlation betweeneosinophilcounting and LC3 expression 23 7. Localization of autophagy in severe asthma model 25 8. The effect of asthma drugs on …
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TL1A Priming Induces a Multi-Cytokine Th9 Cell Phenotype That Promotes Robust Allergic Inflammation in Murine Models of Asthma
… pleiotropic cytokine IL-9 which has functions in allergic airway disease, helminth infections, and tumor immunity. TL1A increases IL-9 production from Th9 cells. However, its role in regulating other functions of Th9 cells is unknown. Here we demonstrate that TL1A increases expression of IL-9 and …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
Inflammation occurs in many chronic lung diseases including pulmonary arterial hypertension (PAH) and asthma, however, the mechanisms underlying these diseases are not well understood. This thesis reports the findings from two studies that examined the role of the bone morphogenetic protein type II …
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Transcription factors and cis-acting elements in T helper cell cytokine expression
… but can also respond inappropriately causing allergic inflammation and autoimmune disease. CD4+ T cells, which play a crucial role in adaptive immune system, can be divided into several subsets based on their effector functions. T helper 9 (Th9) cells, derived by the IL-4/STAT6 and TGF-β …
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Ambient particulate matter as a trigger for acute exacerbations of asthma
… of asthma. The mechanism(s) by which non-allergic stimuli such as particulate pollutants trigger exacerbations of allergic asthma are unknown, but may involve injury to airway epithelial cells (AEC) via oxidative stress. Objective: To assess the ability of ambient particulate matter to …
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A mouse model of childhood asthma: mechanisms of development and progression following an early-life respiratory viral infection
… (RSV), are strongly linked to development of allergic asthma. The aim of this project was to develop a mouse model of the induction phase of childhood asthma, to facilitate investigation of the interaction of early-life infection with RSV, subsequent allergen exposure and development of …
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The Role of ASK1 in Allergen-mediated Mast Cell Signaling and Activation-dependent Inflammatory Responses
… targets in allergen-induced mast cell-mediated inflammation is crucial for therapeutic development. Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) that is involved in various cellular responses, including oxidative stress, high calcium concentrations and …
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Differential analysis of scRNA-Seq data to characterize epithelial cells in health and disease
… this can include response to disease, such as allergic inflammation or infection with SARS-CoV2. Studies of these tissues and the cells of which they are composed can allow us to better understand how epithelia respond to diverse perturbations, leading to broad insights in how to mitigate …
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Dissecting the anti-allergic potential of carnosic acid during IgE and IL-33-mediated mast cell activation
… immune sentinels and essential regulators of inflammation, most notably recognized for their central role in allergic inflammation. Allergen-induced cross-linkage of FcεRI complexes initiates a biphasic mast cell response, characterized by the immediate degranulation of preformed mediators and …
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Prolonged T – DC macro-clustering within lymph node microenvironments initiates Th2 differentiation in a site-specific manner
… protect against pathogens while also driving allergic inflammation, yet how large-scale Th2 responses are generated in tissue context remains unclear. Here, we used quantitative imaging to investigate early Th2 differentiation within lymph nodes (LNs) following cutaneous allergen …
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Innate Immune Responses in the Alternaria-Dendritic Cell Interaction
… ubiquitous fungus, is clinically associated with allergic airway disorders including allergic rhinitis, asthma, and chronic rhinosinusitis. Dendritic cells are known as the type of antigen presenting cells most often associated with allergic inflammation. In this study, we used mouse bone …
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Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation
Asthma is characterized, not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered …
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Symptoms and aspects on eosinophil activity in allergic rhinitis
Allergic rhinitis is a major atopic disease. Even if much is known about the pathophysiology of this condition, and despite the fact that good treatments are available, there is a need for new treatment options, particularly for such aiming at new targets and reduced side effects. Recruitment and …
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The Regulation and Function of Thymic Stromal Lymphopoietin Receptor (TSLPR) in the Airway Epithelium
… a key role in the development and progression of allergic disease and has notably been shown to directly promote the inflammatory responses that characterize asthma. Current models suggest that TSLP is produced by epithelial cells in response to inflammatory stimuli and acts upon hematopoietic …
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
… central to the pathogenesis of asthma and other allergic diseases. Th2 cells secrete the cytokines IL-4, IL-5 and IL-13, responsible for many of the features of allergic inflammation such as eosinophilia, IgE production and mucus hypersecretion. Cysteinyl leukotrienes (CysLTs) are known potent …
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Characterizing the Innate Immune Response of Human Airway Cells to the Unique Fungal Allergen Alt a 1
Allergic airway diseases such as rhinitis, asthma, and chronic rhinosinusitis are responsible for causing a huge economic burden on patients and society. Patients suffering from asthma often have allergies to pollen, dust mite, and mold. Interestingly, studies have shown that there is a correlation …
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Airway Inflammatory States in Response to Environmental Pollutants and the Influence of Oxidative Balance
… of asthma cases. The pathophysiology of airway inflammation and hyperresponsiveness in relation to air pollution is not well understood. Based upon previous experiments, this study hypothesized that key components of air pollution, specifically sulfates and aldehydes, enhance allergic …
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Correlation between Locally Produced Specific IgA and Eosinophil Cationic Protein in Nasal Lavage Fluids of Allergic Rhinitis Patients during Allergen Provocation Tests
… are the major effector cells in nasal allergic inflammation. However, the mechanism of eosinophil activation mediated by a series of inflammatory mediators presenting in early and late responses of allergic rhinitis (AR) is not fully understood. Objective: The aim of this study was to …
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