Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Allergic Asthma"”.
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Investigation of immune responses in different mouse models of allergic asthma
… Understanding the immune responses during allergic diseases is essential for both diagnosis and the development of effective therapies. The route of sensitisation to allergens is one factor that influences the immune response and the outcome of allergic diseases and both human and animal …
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Expanding Allergen-specific Tr-1 CD4+ T cells to treat Allergic Asthma
Asthma is a chronic inflammatory disease of the lungs, which is one of the most frequent chronic disease in industrialized nations. The associated morbidity and occasional mortality rates are secondary to an underlying dysfunction of the airway driven by immune-mediated inflammation. Our lab has …
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Development of vaccines against allergic asthma using products derived from intracellular bacteria or helminths
… auf ihre Effektivität getestet, allergisches Asthma in der Maus zu unterdrücken. Alle Adjuvantien konnten die durch Allergie induzierte Lungeneosinophilie, die Schleimproduktion in der Lunge und mit Ausnahme von PPD, die Lungenüberempfindlichkeit (AHR) unterdrücken, wenn sie zusammen mit …
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Functional Responses of Lung Dendritic Cell Subsets in Flt3 Ligand-Induced Immunomodulation in Allergic Asthma
Asthma is an inflammatory airway disease characterized by airway eosinophilia, airway obstruction due to an increased mucus production by goblet cells, airway remodeling, and airway hyperresponsiveness (AHR) to a variety of stimuli. In allergic airway inflammation, dendritic cells (DC) deliver …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
<p>The prevalence of asthma has markedly increased in recent decades. Asthma affects approximately ten percent of the population of the United States, and is the leading cause of childhood hospitalization. This epidemic has been attributed to air pollution, childhood immunizations and a more …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
<p>The prevalence of asthma has markedly increased in recent decades. Asthma affects approximately ten percent of the population of the United States, and is the leading cause of childhood hospitalization. This epidemic has been attributed to air pollution, childhood immunizations and a more …
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis
… non-harmful substances known as allergens. Both allergic asthma and atopic dermatitis (AD) are said to be induced by elevated levels of immunoglobulin E (IgE) and T helper 2 (Th2) immune cells and inflammatory associated cells such as eosinophils, mast, and basophils. Globally, asthma is …
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IGF1R as a pharmacological target in allergic asthma and cancer-promoting factor in the lung tumor microenvironment
IGF1R (receptor del factor de crecimiento similar a la insulina tipo 1) es una tirosina quinasa ubicua que modula múltiples funciones celulares, como la proliferación, el crecimiento, la diferenciación y la supervivencia. El asma es una enfermedad pulmonar crónica caracterizada por obstrucción …
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Chloride Channel 3 (CLC3), an Immune Antiporter in the Migration and Activation of Human Eosinophils in Allergic Asthma
Allergic asthma is a complex and heterogeneous disease of the airways. Eosinophils migrate to the airways under the influence of chemokines to start an excessive damage and repair cycle leading to airway inflammation and remodeling in allergic asthma. TGF-β has been closely related with eosinophils …
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Development and Testing of Pharmacological Tools to Evaluate the Role of Protease-Activated Receptor-2 in Allergic Asthma
Despite the variety of asthma pharmacotherapy options that exist, a large subset of asthma patients present with poorly controlled disease. Extensive studies supporting a central role for Protease-Activated Receptor-2 (PAR2) in allergic asthma pathophysiology have promoted drug development efforts …
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… on airway inflammation in a mouse model of allergic asthma. MATERIALS AND METHODS: Sensitized BALB/c mice were intragastrically treated withP113(30mg/kg) 30 minutes before OVA challenge. Airway responsiveness (AHR), cell composition and cytokine levels in bronchoalveolar lavage (BAL) fluid …
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The temporal requirement of IL-4Rα signalling in allergic asthma and the role of IL-4Rα-responsive Regulatory T cells in restraining allergic airway inflammation
Allergic asthma is a chronic inflammatory airway disease driven predominantly by a TH2 immune response to environmental allergens. The asthma pathology is predominantly elicited by IL-4 and IL-13 signalling via IL-4Rα-signalling which is essential for driving TH2-type immunity to allergens. …
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Allergen Sensitization and Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model
<p>Allergen-induced asthma is the leading form of asthma and a chronic condition worldwide. Common allergens are known to contribute to the pathogenesis of this disease. Murine models of allergic asthma have mostly used an intraperitoneal route of sensitization (not airway) to study this disease. …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
… pulmonary arterial hypertension (PAH) and asthma, however, the mechanisms underlying these diseases are not well understood. This thesis reports the findings from two studies that examined the role of the bone morphogenetic protein type II receptor (BMPR2) and the mammalian target of …
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Traffic pollution and chronic respiratory disease. Epidemiological studies in children and adults in southern Sweden.
… close to dense traffic had higher prevalence of asthma and COPD. Paper 2 found that adults living close to dense traffic had higher prevalence of allergic asthma, allergic rhinitis and eczema but not non-allergic asthma or rhinitis. Paper 3 found that asthma in adults was associated with dense …
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Autoantibodies From Patients With Nonallergic Asthma Cause Cytotoxic Injury To Airway Epithelial Cells.
… airway epithelial cells in serum samples of nonallergic asthma compared to allergic asthma and healthy controls have been reported. And a possible involvement of autoimmune response against bronchial epithelial cell antigen in the pathogenesis of nonallergic asthma has been suggested. To …
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In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma
… beta-2 adrenergic receptor abnormality in allergic asthma could be induced, induced by autoantibodies. I established and optimised beta-2 adrenergic receptor ligand binding and functional assays in guinea pig lung membranes and then conducted an original study of beta adrenergic receptor …
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Phenotypic and Functional Analysis of Regulatory T Cells during Heligmosomoides polygyrus infection
… shown to downregulate inflammatory as well as allergic conditions such as Crohn’s Disease, Ulcerative Colitis and allergic asthma respectively. However, the differences in the Tregs generated during helminth infection compared to steady state natural T regs have yet to be fully elucidated. …
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Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
Asthma is one of the most common chronic diseases in the world, affecting approximately 300 million people worldwide. Asthma has many phenotypes, allergic asthma being the most common form. Most cases are initiated by IgE antibodies, generally referred to as IgE-mediated allergic asthma. Treatments …
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