Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"All-trans retinoic acid"”.
-
DEVELOPMENT AND CHARACTERIZATION OF POLYMER-OIL NANOSTRUCTURED CARRIER (PONC) FOR CONTROLLED DELIVERY OF ALL-TRANS RETINOIC ACID (ATRA)
… stability. PEG-PONC has demonstrated substantially superior activity over the free ATRA in ovarian cancer cells that are non-responsive to the standard chemotherapy. The newly developed PEG-PONC significantly reduced the IC50 values (p<0.05) in the chemoresistant cells in both MTT and colony …
-
Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
All-trans retinoic acid (ATRA) is successful in treating acute promyelocytic leukemia but has shown limited success with other cancers. Identifying signaling pathways that confer ATRA responsiveness and compounds that enhance the effects of the drug could expand its therapeutic efficacy. The …
-
Directed differentiation of endodermal cells from mouse embryonic stem cells
… as precursors for pancreas and liver. By using all-trans-retinoic acid, basic fibroblast growth factor, dibutyryl cAMP, and cyclopamine, an attempt has been made to produce definitive endoderm and subsequently cells that can serve as pancreatic and hepatocyte precursors from mouse embryonic stem …
-
Evaluation of the role of autophagy in acute myeloid leukaemic cell differentiation
… therapy’. The best example of this is the use of all-trans-retinoic acid (ATRA) in the treatment of acute promyelocytic leukaemia (APL). The differentiation of APL cells treated with ATRA in vitro is a model that allows the examination of differentiation pathways in myeloid leukaemic cells. Using …
-
The Role of Retinoic Acid in the Formation and Modulation of Invertebrate Electrical Synapses
… in nature, owing to the type of signals that are transmitted across them. Factors that can affect chemical synapses have been extensively studied. However, the factors that can influence the formation and modulation of electrical synapses are poorly understood. Retinoic acid, a vitamin A …
-
The Effect of HACE1 on RAR Protein Stability
All-trans retinoic acid (RA), as a ligand for retinoic acid receptors (RAR) and retinoid X receptors (RXR), modulates their transcriptional activity. The AF-1 and AF-2 domains mediate the transcriptional activity. The ligand dependent activation of the AF-2 domain by RA is well understood to …
-
Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… array, while 3) the anti-tumorigenic agents all-trans retinoic acid and interferon alpha up-regulate CysLT2R expression in colorectal cancer cells; 4) LTC4, a ligand for CysLT2R, inhibits migration of colorectal cancer cells; 5) Intestinal epithelial and colorectal cancer cells express …
-
Regulation of NF-κB by PML and PML-RARα
The transcription factor NF-κB is the master regulator of the immune response but also acts broadly to regulate gene expression that influences cell survival, proliferation and differentiation. Post-translational modification of NF-κB, phosphorylation in particular, is essential for the …
-
The role of p27 phosphorylation in mediating atRA sensitivity of ovarian carcinoma cells
All trans retinoic acid (atRA) has been shown to inhibit the growth of CAOV3 ovarian carcinoma cells. This results from arrest of the cell cycle during the G1 phase. G1 checkpoint is regulated by a multitude of molecules, including the retinoblastoma family of proteins, cyclin dependent kinases …
-
Structure and Function of a Cytochrome P450 From Synechocystis Sp. PCC 6803
… and provide interesting and crucial metabolic transformations. The search for novel functions and the revelation of new structures thus demands exploration of cytochrome P450s in novel econiches. Cyanobacteria, photosynthetic bacteria, are thought of as the ancestors of chloroplasts. They …
-
Signaling Cross-Talk Regulating the Expression of Arginase 1 in Murine Macrophages
… (IL-4), a cytokine secreted by Th2 helper cells. All-trans retinoic acid (ATRA) is a product of metabolism of dietary retinol (vitamin A). In a manner analogous to hormones, ATRA binds to nuclear receptors in cells and influences gene expression and cell physiology. ATRA is important in the …
-
Interaction between retinoids and methyl group metabolism
… donation of carbon in the production of nucleic acids from folate coenzymes and the methylation of biological compounds via transmethylation metabolism is important for maintenance of cells and tissues. Disruption of these tightly regulated pathways can result from genetic polymorphisms of key …
-
Synthetic Degradable Polymer Systems for Drug Delivery
… (OA) is a degenerative disease that affects all joint tissues, leading to pain and loss of mobility, with no current disease-modifying drugs available to slow or halt its progression. Intra-articular (IA) delivery has the potential to target joint tissues and minimize the side effects of new …
-
Apolipoprotein M – Studies of Structure and Function
… M (apoM), a 25 kDa plasma protein, is found in all major lipoprotein classes, although the majority is found in high density lipoproteins (HDL). ApoM has been suggested to be involved in the formation of and adding to the antiatherogenic functions of HDL, but its function is still not completely …
-
Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… and malignant primary prostate cancer cells with all-trans retinoic acid (atRA) also resulted in increased expression of ALDH1A3 and ALDH3A1, supporting a feedback loop between atRA and ALDHs. Furthermore, SerBob, Bob and LNCaP cells were sensitive to treatment with epigenetic drugs and led to …
-
Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… and malignant primary prostate cancer cells with all-trans retinoic acid (atRA) also resulted in increased expression of ALDH1A3 and ALDH3A1, supporting a feedback loop between atRA and ALDHs. Furthermore, SerBob, Bob and LNCaP cells were sensitive to treatment with epigenetic drugs and led to …
-
Steered molecular dynamics: a tool to investigate molecular interactions
… rates. The applied forces reduced the overall binding energy sufficiently to yield unbinding within the measurement time. The simulations revealed a variety of unbinding pathways, the contribution of amino acid residues and water molecules to adhesion, as well as the spatial range over …
-
The Physiological Effects of CD38 in Prostate Cancer: A multifunctional NAD'ase capable of regulating cell metabolism, gene expression, and therapeutic response
… adenine dinucleotide (NAD+) is linked all aspects of cell metabolism though its ability to act as both an oxidizing and reducing agent for hydride transfer reactions. Proper regulation of NAD+ is also vital to cells as it also serves as a substrate for three classes of NAD+ dependent …
Page 1 of 2