Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Alkylating agents"”.
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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents
Methylating agents are ubiquitous in our internal and external environments and can cause damage to all cellular components, including our DNA. If left unrepaired, methylated DNA can cause mutations, cell death, and disease, such as cancer and neurodegeneration. The majority of DNA lesions caused …
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DERIVATIVES OF 1-PHENYL-1-NONEN-3-ONE AS POTENTIAL BIOLOGICAL ALKYLATING AGENTS
… presented. Unsaturated ketones are known to have alkylating properties. 1-Phenyl-1-nonen-3-one (51) and nuclear substituted derivatives were prepared as potential biological alkylating agents. The influence of aromatic substituents and the length of the alkyl side chain in relation to biological …
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MANNICH BASES DERIVED FROM STYRYL ALKYL KETONES AND THEIR HYDRAZONE ANALOGS AS POTENTIAL ALKYLATING AGENTS
… different classes of drugs are used. Of these, alkylating agents constitute about 30%. Today a few of the less common cancers can be effectively treated by chemotherapy or adjuvant therapy but the majority of the cancers cannot be treated satisfactorily. The drugs that are in clinical use are …
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PART I: ALDOL REACTIONS OF 1,3-OXATHIOLAN-5-ONES. PART II: CAMPHOR AS A CHIRAL DIRECTING AGENT IN ALKYLATIONS OF GLYCINATES.
… were successful only with very reactive alkylating agents.('2,3) Aldol reactions were more successful. 1,3-Oxathiolan-5-ones were reduced with lithium aluminum hydride to 2-mercaptoalcohols, which could be transformed into the 2-(methylthio)alcohols. Part II. Camphor imines of glycinates …
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Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice
… homologous recombination in eukaryotic cells. Alkylating agents are abundant in our environment and are generated endogenously as normal metabolites. In addition to their mutagenic and cytotoxic effects, alkylating agents stimulate homologous recombination in eukaryotic cells. Removal of …
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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION
… as a store of genetic information. Originally, alkylating agents were used as "mustard gas" and related chemical weapons in World War I. Alkylating agents, in general, can react with one or two different 7-N-guanine residues and could potentially result in the cross-linkage of DNA strands, …
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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION
… as a store of genetic information. Originally, alkylating agents were used as "mustard gas" and related chemical weapons in World War I. Alkylating agents, in general, can react with one or two different 7-N-guanine residues and could potentially result in the cross-linkage of DNA strands, …
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Two versatile cofactors, flavin adenine dinucleotide and non-heme iron, involved in DNA repair and natural product halogenation
… protein that is up-regulated in the presence of alkylating agents. AidB contains FAD; however, the precise role of the FAD has been determined. AlkB, another adaptive response protein that is up-regulated in the presence of alkylating agents, is a member of the alpha-ketoglutarate (aKG) non-heme …
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Biological and Functional Consequences of Single Nucleotide Polymorphisms of the O6-Methylguanine-DNA-Methyltransferase Gene
… effect on macrolesion damage after exposure to alkylating agents. However a strong effect of coding SNPs on microlesion damage was observed. The luciferase expression data demonstrated a significant increase in promoter activity in the presence of the enhancer SNP compared to the wild-type form. …
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THE ROLE OF ACTIVE AND ACTIVE-SITE ALKYLATED HUMAN O6-METHYLGUANINE-DNA METHYTRANSFERASE (MGMT AND R-MGMT) IN DNA REPAIR AND BIOMONITORING
… protects cells against the mutagenic effect of alkylating carcinogens, was found to be localised in the nucleus (except the nucleolus) by immunofluorescence staining using polyclonal and monoclonal antibodies. The supporting experiments came from differential staining of the GMT-deficient (mer-) …
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Exploration of Synthetic Pathways to Quaternary Carbon Stereocenters and Fused Ring Systems via Birch Reductions
… and the use of some of the most complex alkylating agents to date.</p>
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Endocrine Effects of Cancer Chemotherapy
… adverse effects. It categorizes chemotherapeutic agents based on their mechanisms of action and their impact on endocrine function, highlighting both intended hormonal modulation and unintended endocrine toxicities. The thesis adopts both a pharmacological and organ-specific approach, detailing …
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The impact of cytotoxic chemotherapy on somatic mutation in normal human cells
… cells with chemotherapy drugs and environmental agents *in vitro* demonstrated mutational signatures associated with a wide range of agents. Alkylating and platinum-based agents were the most mutagenic classes of chemotherapeutics, with all 13 alkylating agent drugs and all four platinum-based …
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Characterization of O6-Methylguanine DNA Methyltransferase and Base Excision DNA Repair Activity in Xiphophorous Fishes
Treatment of cells and/or DNA with direct acting alkylating agents (i.e. methyl-methane sulfonate; MMS, methyl nitrosourea; MNU, N-methyl-N-nitro-N nitrosoguanidine; MNNG) produces a wide spectrum of DNA adducts. The most frequent base adducts formed by alkylating agent exposure include those …
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A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
… in responses to mechanistically distinct toxic agents; in Chapter 5, a series of studies was designed to test the hypothesis that each of these unique signatures represents a common response to different toxicant classes. To test this hypothesis, yeast cells were exposed to four different …
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Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity
… of cells; and (b) demonstrated that exposure to alkylating agents induces physiological MN-formation in erythroid populations derived in vitro. The potential for increased efficiency in this in vitro model depends on the ability to stimulate terminal erythroid differentiation at an optimal level …
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Synthesis of biologically active heterocyclic compounds
… more effective and selective. Nitrogen mustard alkylating agents crosslink DNA inhibiting transcription and replication. Use of the mustard pharmacophore as part of a macrocycle allows metal complexation and produces a prodrug. Hypoxic tumour cells have increased concentrations of reductase …
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The synthesis of derivatives of naturally occurring naphthalenes
… can be structurally defined as bioreductive alkylating agents have considerable potential as antineoplastic agents, according to H.W. Moore (Science, 1977). The protoaphins possess certain structural features which suggest their capability to function as such alkylating agents. Reductive …
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The synthesis and reactions of sulphur analogues of deoxyvasicinone
… Reaction of the anion derived from (B) with alkylating agents, Michael acceptors and activated halopyridines afforded novel substituted derivatives. The oxidation, Pummerer rearrangement and deacetylation of (A)-(C) was accomplished to yield analogues which were similar in structure to the …
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The versatile E. coli adaptive response protein AlkB mitigates toxicity and mutagenicity of etheno-, ethano-, and methyl-modified bases in vivo
… Its expression is induced upon exposure to alkylating agents as part of the Ada-mediated adaptive response. This member of the ac-ketoglutarate/iron(II)-dependent dioxygenase family was originally discovered to reverse directly methylated lesions formed preferentially in single-stranded …
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