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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Alkylamines"”.
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Direct ⍺-C–H Functionalisation of Cyclic Alkylamines
Saturated N-alkyl heterocycles are among the most important structural motifs in natural products, small-molecule biological probes and pharmaceutical agents. Substituted derivatives of these cyclic tertiary alkylamine scaffolds often exhibit markedly different physicochemical and biological …
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Reductive elimination of alkylamines and ethers: reactions of bisphosphine-ligated palladium(II) complexes
The reductive elimination reactions detailed in this dissertation provide experimental insight into the mechanism of reductive elimination to form the C(sp3)-N bond of benzylamines and the C(sp3)-O bond of benzyl ethers. The stereochemical outcome of the reaction indicates an ionic pathway, but the …
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Tertiary alkylamines as effective directing groups for palladium-catalysed C(sp3)–H activation strategies
… Within the last decade, primary and secondary alkylamines have been reported to direct C–H cleavage on a series of palladium-catalysed reactions. The work reported in this dissertation describes the development of a new palladium-catalysed strategy towards the functionalisation of aliphatic …
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Modular Methods for the Synthesis of α-Tertiary and α-Branched Alkylamines via Visible-Light-Mediated Radical Generation
… is a central goal of organic synthesis. Alkylamines are interesting synthetic targets because they occupy a privileged position in drug discovery yet are often highly challenging to synthesise. Complex alkylamines commonly feature branching at the α-position, which can further complicate …
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Aspects of the chemistry of 1,4-naphthoquinones. An investigation of nucleophilic substitution reactions of alkylamines and hydroxyalyklamines on 1,4 napthoquinones and the role of solvent on the position of substitution.
Nucleophilic substitution reactions of alkylamines, cyclic alkylamines, and hydroxyalkylamines with 5-substituted-1,4-naphthoquinones have been studied. It has been found that the nature of the solvent employed in the reaction influences the position of mono-substitution at either the 2- or …
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New strategies for the synthesis and functionalization of aliphatic amines
… catalyzed processes for the synthesis of alkylamines that attempts to meet this challenge. The first Pd-catalyzed methylene β-C−H carbonylation of alkylamines to form substituted β-lactams is reported. Through the synergistic use of a Pd-catalyst and Xanpthos ligand, secondary amines …
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Gold(I) and Platinum(II)-Catalyzed Hydrofunctionalization of Allenes and Alkenes with Carbon and Nitrogen Nucleophiles
… of monosubstituted allenes with secondary alkylamines in good yield with selective formation of (<italic>E</italic>)-allylic amines. The scope of the protocol included aryl and alkyl monosubstituted allenes as well as a variety of both cyclic and acyclic secondary …
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New strategies for the synthesis and homologation of complex aliphatic amines
… assembly and late-stage modification of complex alkylamines represents a significant and enduring challenge in synthetic chemistry. This is due to the ubiquity of this chemical motif in biologically active small molecules and therapeutic agents. This thesis describes the design and implementation …
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Methods Development in Chiral Chromatography
… amino acids, amides of 1-aryl-1-alkylamines and N-2-naphthyl amino acids have proven to be viable sorbents for the direct liquid chromatographic separation of enantiomers. In an effort to extend the utility of these chrial stationary phases, a variety of analytical methodologies …
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Some aspects of quinonoid chemistry
… - 3,6 - dianilino - 1,4 - benzoquinone with alkylamines in chloroform. Irradiation of these alkylamino - p -benzoquinones with ultra-violet light gave benzoxazoles where an á -hydrogen atom was present in the alkylamino substituent, except for the cyclohexylamino - and s - butylamino - …
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New carbon-nitrogen bond-forming reactions of palladium
… C(sp3)-N bond-forming reductive elimination of alkylamines. Three-coordinate norbornylpalladium anilido complexes ligated by bulky monodentate N-heterocyclic carbene (NHC) ligands undergo thermal reductive elimination to generate alkylamine products. The stereochemistry of the norbornylamine …
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METAL-FREE SELECTIVE SP3 C-H IMINATION AND COVALENT POSTSYNTHETIC MODIFICATION OF POLYSTYRENE BY DIRECT C-H AMINATION
… methods enabling direct alkane C–H amination. Alkylamines are commonly found as natural products and bioactive compounds, and amino functionalization can improve the properties of commodity polymers. Transition-metal-catalyzed C–H amination has emerged as a powerful tool for C–N bond formation, …
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Probing the Role of Amines in Aqueous Electrochemical Reduction of Captured-state CO₂
… cell performance. We chose a subset of primary alkylamines with varied steric hindrance and pKₐ and evaluated each on the basis of Faradaic efficiency, partial current density to reduced products, and the dynamics of product formation on Ag-based electrocatalysts. Through these measurements, we …
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Controlled polymerization of alkyl vinyl ethers via 'covalent' propagating species
… reaction and amination reactions. Linear alkylamines with lower carbon numbers are used in the amination reaction in order to promote the nucleophilic substitution reaction and to minimize possible elimination reactions. A series of amine functionalized oligomers are synthesized by …
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A facile hybrid method to synthesize metal and metal chalcogenide nanoparticles using various capping groups
… nanoparticles were elongated when capped using alkylamines such as hexadecylamine (HDA) and OA, however at low temperature of 90oC they appeared to be close to spherical. The antimony chalcogenides, Sb2S3, Sb2Se3 and Sb2Te3 gave a similar rod shape morphology. The Sn nanoparticles appeared …
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Asymmetric synthesis of benzylic and heterobenzylic amines
… gave the N-substituted-1-(2-pyrrolyl)alkylamines with high yields and diastereoselectivities. The (S,S)-diastereomers were useful intermediates for the preparation of enantiopure 1-[1-(2-pyrrolyl)alkyl]aziridines by routine cyclization of the β-aminoalcohol moiety and of (S)-N-benzoyl …
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Synthesis and patterning of reactive silver inks
… we created a hybrid reactive silver ink in which alkylamines are incorporated with ammonium hydroxide. This ink is particle-free and optically clear, yet undergoes rapid particle formation upon patterning as evaporation promotes silver reduction. This ink exhibits both a higher viscosity (7.3 …
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Chemistry of fused-ring iridabenzenes
… be used to prepare simple derivatives such as alkylamines, sulfonamides, amides, as well as more unusual imide derivatives. The ancillary ligands and formal charge were again found to be important in determining the stability and extent of the reactions. The rst metallabenzene derivatives …