Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"Alkyl Halides"”.
-
Cross-coupling reactions of unactivated alkyl halides
… cross-coupling reactions using unactivated alkyl electrophiles (e.g., halides and sulfonates). Although aryl and alkenyl electrophiles have been commonly used in such processes, the utility of alkyl substrates has been underdeveloped, and merits further exploration. We have developed the …
-
A study of the self-diffusion of certain of the lower alkyl halides
The self-diffusion coefficients of Mel, and Et-, nPris-,isoPr-, nBu-, isoBu- and secBu-iodides and bromides were determined by application of the capillary tube method and using iodine-131 and bromine-82 for labelling the compounds. Viscosities were measured for those compounds for which the data …
-
Halonium Ylid Intermediates in the Photodecomposition of 3,5-Dialkylbenzene-1,4-Diazooxides in Alkyl-Halides and Aryl-Halides
Made available in DSpace on 2014-12-10T23:01:25Z (GMT). No. of bitstreams: 1 7309881.pdf: 2049741 bytes, checksum: 9a0e5e1b3b41eb6f753b80d2804481f3 (MD5) Previous issue date: 1972
-
Nickel-catalyzed cross-couplings of unactivated secondary and tertiary alkyl halides and photoinduced copper-mediated asymmetric C-N cross-couplings
… Suzuki cross-coupling methodologies that employ alkyl halides as electrophiles. In Section 1.1, asymmetric [gamma]-alkylation relative to a carbonyl group is achieved via the stereoconvergent cross-coupling of racemic secondary [gamma]-chloroamides with primary alkylboranes. Section 1.2 describes …
-
Investigating carbocations using high speed ball milling
… conditions; the results were that primary alkyl halides undergo substitution reactions, while the reactions of secondary alkyl halides depend on the nucleophile. However, reactions that form a carbocation intermediate, such as, S<sub>N</sub>1 reaction and pinacol rearrangement have not been …
-
Generation of Alkyl Radicals Via C-H Functionalization and Halogen Atom Transfer Processes
Alkyl radicals are powerful intermediates for the generation of carbon-carbon bonds, which play an indispensable role in the synthesis of natural products, pharmaceuticals, and pesticides. Traditionally, there are two main methods for the generation of alkyl radicals. The first is C-H bond …
-
The sodium borohydride reduction of organic halides and related derivatives in aprotic solvents
Sodium borohydride reduces alkyl halides and their related tosylate derivatives in the order primary > secondary > tertiary, while the relative order of leaving-group ability is Ts⁻ ≥ I⁻ > Br⁻ > > Cl⁻. The yields obtained ranged from 90-100% for most simple, primary and secondary iodides, bromides, …
-
Reductive Alkylation Reactions Using Tetramethyldisiloxane and Potassium Tert-Butoxide Via Reductive-Radical Polar Crossover
… the formation of C(sp3)-C(sp3) bonds: the hydroalkylation of vinylarenes (chapter 2), and the cross-electrophile coupling of alkyl halides (chapter 3). This simple system of commonly available reagents is suspected to form a hypercoordinate silicon complex capable of acting as a single-electron …
-
Cobalt-catalyzed Kumada coupling and the development of a CC ligand and metalation to cobalt
… Co(I) complexes for amination of aryl halides, a Co(acac)3¬/PN precatalyst was developed and optimized for catalytic Kumada coupling of aryl Grignard reagents to sterically encumbered alkyl halides. The substrate scope demonstrates excellent yields for primary alkyl chlorides and …
-
Enantioselective lateral lithiation-substitution of o-ethyl- and o-benzyl-N-pivaloylanilines: Studies of a pathway of stereoinformation transfer
… of whether stannyl or stannyl chlorides, alkyl halides, or aldehydes and ketones are used as the electrophile.
-
Synthesis and Physical Investigation of some Organotellurium Compounds
… stability toward the reductive elimination of alkyl halides in solutions such as CHC13, DMSO and DMF. The idea of association of the telluronium salts is now firmly established, and is supported by mass spectral and molecular weight data. 1H, 125Te and 13C NMR spectral data are presented. The …
-
INVESTIGATIONS OF HYPERVALENT IODINE COMPOUNDS IN ORGANIC TRANSFORMATIONS
… a surprising reaction between IBX or IBA and alkyl halides promoted by quaternary ammonium halides. In the absence of quaternary ammonium halides, no reaction occurred between IBX or IBA and alkyl halides. However, in the presence of quaternary ammonium halides, IBX or IBA and alkyl halides …
-
Synthetically Useful Dipole-Stabilized Carbanions From Thioesters and Thiocarbamates
… react with electrophiles including primary alkyl halides and a variety of carbonyl compounds to give substituted thioesters. Study of the optically active 2-octyl thioester as well as the cis-4-tert-butylcyclohexyl thioester has shown that (alpha)-lithio thioesters are not configurationally …
-
Brønsted acid-catalyzed alkylation of tetrazoles with alcohols
… activities. Traditionally, tetrazoles have been alkylated using alkyl halides under basic conditions. However, alcohols are the most convenient alkylating reagents. While Lewis and Brønsted acid-catalyzed alkylations of tetrazoles using alcohols have been reported, their drawbacks include the …
-
Cesium Effect: A Mild and Efficient Synthesis of Secondary and Tertiary Phosphines
… and DMF, at room temperature, a wide range of alkyl halides has been coupled to primary or secondary phosphines to yield secondary or tertiary phosphines. Included were activated and aliphatic halides, as well as base sensitive functional groups. In addition, examples of disecondary and …
-
Synthesis of Bisubstrate Analog Inhibitors against Aspartate Semialdehyde Dehydrogenase
… of secondary amine derivatives and phenyl alkyl halides. The two synthons are being coupled through nucleophilic substitution followed by hydrolysis to form the desired bisubstrate analogues. Four compounds were identified based on docking score and selectivity analyses. These analogs were …
-
Investigation of synthetic methods for preparation of 2<sup>o</sup>-amino derivatives of 5-amino- 1, 10-phenanthroline: Applications to Cu<sup>+2</sup> based impedance sensors
… hulls. The importance of the planned secondary alkyl amino derivatives will be to test their binding properties to the gold surface through dithiocarbamate linkages by monitoring the IDE impedance signal. Practical sensor development requires good impedance response, maximum binding to the gold …
-
An investigation of the chemistry of lithiotriphenylphosphineacetylmethylene
… -78º. This ylide anion reacted selectively with alkyl halides to form γ-substituted 13-keto phosphonium ylides. Subsequent ionization of triphenylphosphine-(3-phenylpropionyl)methylene with n-butyllithium at -78° followed by alkylation produced γ,γ-disubstituted ylides. Condensation of the ylide …
-
Study of Synthesis, Reactions and Enantiomerization of C<sub>α</sub>-Chiral Grignard Reagents
… reagents. Examples of Mg/X exchange reactions of Alkyl (sp³) halides are, however, rare. Even more rare are such examples with secondary and tertiary alkyl halides, justifying the relative paucity of chiral Grignard reagents. In this module of our project, we study the Mg/X exchange reactions on …
Page 1 of 3