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Showing 1 to 7 of 7 for “"Alkenylation"”.
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“Trans-Positioning” Carbons within Strained Caged Bicyclic(s): ROM/RCM (Ring-Opening/Ring-Closing) Metathesis and Dieckmann/Retro-Dieckmann Condensation Routes to a Cis-Decalin Infrastructure
… ultimately for skeletal rearrangement. Trans-alkenylation and trans-acylation processes are devised for investigation with bicyclo[2.2.2]octyl and bicyclo[2.2.1]heptyl strained cores. Recent advances in olefin metathesis led to an independent proposal of the now applicable, RRM …
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Palladium-Catalysed Functionalisation of Csp3–H Bonds Directed by Aliphatic Amines
… Chapter 3 describes a palladium-catalysed Csp3–H alkenylation directed by tertiary aliphatic amines. A diverse set of amines were functionalised using alkenyl boronic ester coupling partners to give the desired olefinated products. The work includes enantioselective functionalisation using a …
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Towards the Development, Application and Understanding of Copper-Catalysed Alkene Functionalisation Processes Using Iodonium Salts
… the application of a copper-catalysed oxy-alkenylation procedure to the production of the macrolidal natural product (-)-lyngbyaloside B. It is proposed that an elaborate homoallylic carbamate may be coupled with a complex polyoxygenated alkenyl(aryl)iodonium salt as a fragment coupling for …
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The selective palladium-catalysed decarboxylative coupling of nucleophiles in the presence of propargylic electrophiles
… manner. Focus is given to the enantioselective alkenylation and enantioselective allylic alkylation reactions. Optimisation of the reaction conditions as well as the expansion of the substrate scope is described. Finally, a discussion of future work, comprehensive conclusions as well as …
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Mechanism and application of Lewis and Brønsted acid effects in organotransition metal catalysis
… of LiOTf, a Mizoroki-Heck type reaction, the alkenylation of an aryl halide with a vinyl ether, proceeds with regioselectivity. In the absence of LiOTf, a solvent (CH3CN) activation pathway proceeds to give benzyl nitrile products. High throughput microscale reactions discovered that the …
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Direct Brønsted acid-catalyzed functionalization of benzhydryl alcohols and 2-ethoxytetrahydrofuran using potassium trifluoroborate salts
Metal-free transformations of organotrifluoroborates are advantageous since they avoid using frequently expensive and sensitive transition metals. Lewis acid-catalyzed reactions involving organotrifluoroborates have emerged as an alternative to metal-catalyzed protocols. However, these methods rely …
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Brønsted Acid-Catalyzed Reactions of Vinylboronic Acids and Benzhydryl Alcohols
The functionalization of benzhydryl alcohols is an approach to form important building blocks in organic synthesis. More specifically, the derivatization of benzhydryl alcohols to afford an alkene is a desired approach due to the wide variety of derivatizations applicable to 1,3,3-triphenylpropene …