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Showing 1 to 2 of 2 for “"Aleutianamine."”.
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Total synthesis of ent-plagiochianin B and development of a metathesis approach to aleutianamine.
… and heavily bridged pyrroloiminoquinone alkaloid aleutianamine was isolated in 2019 from the North Pacific sponge Latrunculia (Latrunculia) austini Samaai, Kelly & Gibbons, 2006 and exhibits cytotoxicity against a number of cancer cell lines. Noteworthy is aleutianamine's IC 50 value of 25 nM …
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Total synthesis of polycyclic natural products : synthetic studies on (+)-ineleganolide, (–)-sinulochmodin C, verrillin hydrate, and aleutianamine.
… polycyclic pyrroloiminoquinone alkaloid, (+)-aleutianamine, from the marine sponge Latrunculia austini. The natural material was found to possess potent and selective cytotoxicity in vitro against a human pancreatic cancer cell line (PANC-1, IC50 = 25 nM). This remarkable and unprecedented …