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Showing 1 to 18 of 18 for “"Alendronate"”.
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Alendronate treatment elicits a reduction in fatigue-life of canine cortical bone
… bone tissue after bisphosphonate treatment with alendronate (Aln). 1 1th ribs from 36 skeletally mature female beagles (1-2 years of age) treated daily with either a vehicle control (Cont, 1mL/kg saline) or Aln (0.2 or 1.0 mg/kg) for 3 years were evaluated. From both medial and lateral cortices, …
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Alendronate Alters Single Cell Gene Expression of Cortical Osteoblast Lineage Cells During Bone Loss
… without the anti-resorptive bisphosphonate drug Alendronate, an effective FDA approved therapeutic for slowing bone loss in association with osteoporosis. To administer Alendronate, mice were treated with 100 μg/kg Alendronate weekly via intraperitoneal (IP) injections. After a 16- week period …
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Cost effectiveness of alendronate to reduce hip fractures from osteoporosis in Icelandic postmenopausal women
… effective to treat postmenopausal women with alendronate to prevent hip fractures. The focus is on Icelandic women. Design: A Markov model was developed to model the disease progression for women 65 years of age to 85 years of age which is the average life expectancy for women in Iceland. Cost …
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Modeling the Long Term Effects of Alendronate on Bone Mass Preservation of the Femur with Articular Surface and Total Hip Replacements
… one year preoperative to one year postoperative Alendronate treatment and one year postoperative Alendronate treatment for a specific implant type. Both treatment scenarios increase the BVF over no treatment. Pretreating with Alendronate appears to help against femoral neck fracture. This study …
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Economic evaluation of three preventive drug therapies for osteoporotic fractures among women at different risk levels
… are: hormone replacement therapy (HRT), alendronate, and raloxifene. Methods. A hypothetical cohort of white women aged 45--85 years, postmenopausal, and without past incidence of osteoporotic fractures was treated with one of the three alternatives, and tracked over 3 years in a decision …
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The Effects of Bisphosphonates on Bone Remodeling: Analysis of Microdamage Targeting by BMUs, BMU Velocity and Crack Surface Density
… beagles were administered the bisphosphonate Alendronate in doses matching, on a body weight basis, those used to treat postmenopausal osteoporosis. Control, clinical dose (Alendronate 0.2 mg/kg body weight), and five times clinical dose (Alendronate 1.0 mg/kg body weight) treatment groups …
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The clinical characteristics, complications and treatment outcomes of patients with osteoporosis at Groote Schuur Hospital
… zoledonic acid alone, 6.1% (n=12) received oral alendronate alone and 13.1% (n=26) initially received alendronate followed by intravenous zoledronic acid. Over 5.2 years there was an improvement in bone mineral density (BMD) of 4.4% at the lumbar spine, while there was slight worsening of BMD at …
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SURFACE MODIFICATION OF TITANIUM AND TITANIUM ALLOYS TO ENHANCE BONE HEALING
… for 7 and 10 days, 3) immobilization of sodium alendronate bisphosphonate on the pre treated titanium surfaces using microseeding method, and 4) tethering of Bioglass® and sodium alendronate bisphosphonate on the titanium surfaces using the electrohydrodynamic spraying method. The surface …
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Restoration of Bone Material and Microstructural Properties after Long-Term Remodeling Suppression
… using <em>in vivo</em> fatigue loading. Both Alendronate and NE-58025 prevented remodeling/repair of bone microdamage. Moreover, suppression of resorption resulted in an increase in microdamage content, loss of osteocyte integrity and pro-osteoclastogenic signals (i.e., RANKL) and locally …
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The Role of Bisphosphonates and Osteoblast Lineage Cells in Promoting Osteogenic and Angiogenic Processes Necessary for Bone Repair
… 5 month, Fisher 344) with the bisphosphonate alendronate (5 mg/kg) following forelimb cyclic compression to create a stress fracture. Early gene expression and histological results demonstrated that short-term alendronate administration improved early angiogenesis and osteogenesis following …
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Assessment of material properties in bone surrounding microdamage
… remodeling suppression using the clinical BP, alendronate [ALN], on local bone material properties. Studies were performed on cortical bone sections from rat ulnae into which fatigue damage had been introduced <em>in vivo</em>. Rat cortical bone does not exhibit baseline remodeling activity, so …
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Identificazione di bersagli terapeutici e realizzazione di tecnologie innovative in oncologia ortopedica
… (PLGA) and an osteotropic bisphosphonate, sodium alendronate (ALE). NP were subsequently characterised for their chemical-physical properties, biocompatibility, and the ability to inhibit osteoclast-mediated bone resorption, and then loaded with DXR. The effectiveness of NP-loaded DXR was …
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The development and application of a normative framework for considering uncertainty and variability in economic evaluation
… use criteria would be to fund treatment with alendronate for women aged 75 years and over with previous fracture and 77 years and over with no previous fracture. An efficient research plan would fund a randomised controlled trial comparing etidronate to no therapy with a sample size of 640. …
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Biomimetic Materials for Biomedical Applications
… nanocrystals at different content of alendronate, a bisphosphonate widely employed in the treatments of pathological diseases associated to bone loss. The coatings displayed a good degree of crystallinity, and the results of in vitro tests indicated that alendronate promotes …
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The Development and Characterisation of a Peptide Delivery Platform to Interrogate the Anticancer Effects of Bisphosphonates
… the nitrogen-containing bisphosphonate (N BP), alendronate (ALN), into a novel anticancer therapeutic through complexation with the RALA peptide. N-BPs inhibit the prenylation of GTPase proteins, which are responsible for cell replication, morphology and signalling, to cause cell death through …
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Driving tissue morphogenetic cascades using tunable nanolayered surface coatings
… with 40% of side-chains functionalized with alendronate, a potent clinically used bisphosphonate. Encapsulation of doxorubicin at 5mg/kg in an LbL-targeted liposome demonstrated potent toxicity. Active targeting of 143B osteosarcoma xenografts in NCR nude mice prolonged tumor accumulation by …
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The evolutionary transition from reptiles to mammals: analyses of body size reduction and separation of middle ear elements from the jaw
… Inhibiting gene expression through anti-TGFb and alendronate injections, in order to prohibit apoptosis and osteoclast formation, resulted in maintenance of the Meckel's cartilage connection beyond the 20-day mark, and indications of MC ossification as well. An ossified MC was also evident in …
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Βιοχημικοί και ιστοπαθολογικοί δείκτες εκτίμησης αποτελεσματικότητας σύγχρονων θεραπευτικών προσεγγίσεων οστεοπόρωσης
Στην παρούσα διατριβή, μελετήθηκε η επίδραση της ατορβαστατίνης στην εξέλιξη της οστεοπόρωσης. Ως πειραματικό μοντέλο επιλέχθηκε ο επίμυς, που, κατόπιν, απώλειας των οιστρογόνων λόγω ωοθηκεκτομής, αναπτύσσει οστεοπόρωση. Η επαγωγή της οστεοπόρωσης επιβεβαιώθηκε με πληθώρα μεθόδων. Αρχικά, (ημέρα 0) …