Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Aldose reductase"”.
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Molecular and Cellular Signaling Mechanisms Elucidating Aldose Reductase Mediated Ischemia-Reperfusion Injury in the Myocardium
… and cellular signaling mechanisms by which aldose reductase (AR) contributes to ischemia/reperfusion (I/R) injury, specifically in the myocardium. It provides a comprehensive overview of the pathophysiology associated with acute coronary syndromes, the mechanisms of normal myocardial …
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Molecular characterization of ALDRXv4, an aldose reductase orthologue isolated from xerophyta viscosa, in response to abiotic stress
Includes bibliographical references (leaves 61-70).
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Applications of mass spectrometry to protein characterization
… is demonstrated by the study of bovine kidney aldose reductase. The protein is blocked at the N-terminus and is not amenable to Edman degradation. Using a strategy of homology comparison, the amino acid sequence was determined solely by mass spectrometric methods. The nature of aldose reductase …
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Isolation of the aldose reductase gene (XvAld1) from the resurrection plant Xerophyta viscosa, and characterisation of the gene product and transgenic plants expressing the gene
The Xerophyta viscosa aldose reductase cDNA (XvAld1) was isolated from a dehydration library. Gene transcripts that are upregulated during stress are normally involved in protection and/ or adaptation, leading to stress tolerance. The genomic organisation of XvAld1 was characterised using Southern …
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Genetic analysis of the microvascular complications of diabetes mellitus
… have suggested that genetic variations in the aldose reductase (ALR2) gene may contribute to the genetic susceptibility to microvascular complications. Aldose reductase is the first and rate-limiting enzyme of the polyol pathway and is implicated in the pathogenesis of diabetic microvascular …
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Taurine depletion and Schwann cell dysfunction in diabetic neuropathy
… glucose response was ablated by inhibition of aldose reductase, nitric oxide synthase as well as antioxidant treatment. Taurine supplementation reduced glucose-induced increases in oxidative stress, lipid peroxidation nitrosative stress and poly(ADP-ribosyl)ation and these effects were not …
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Toward a General Dehydrogenase Enzymatic Scaffold for Industrial Biocatalysis
… inactivation. AdhD belongs to the aldo-keto reductase superfamily, a large and diverse family of oxidoreductase enzymes, and shares the canonical (α/β)8-barrel fold and nicotinamide cofactor binding pocket. AdhD has a strong preference for NAD(H) over NADP(H), and is active with a broad range …
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Protective potential of fruits against diabetes and its complications
… A. chilensis and P. virginiana were explored for aldose reductase inhibitory activity. Overall, fractions from A. chilensis were more active than those from P. virginiana with maximum IC50 activity of 0.7 µg/mL. Fractions with the most activity were positively associated with proanthocyanidin and …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… protein activity since the aldose reductase inhibitors (ARIs) zopolrestat and sorbinil reduced HSF-1 and NFκB-DNA binding activity in PBMCs. In conclusion, these results suggest that NFκB and HSP70-A2 genes may contribute to the genetic susceptibility to TIDM. Uncontrolled …
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Metabolic engineering of yeast for xylose uptake and fermentation
… xylose metabolic pathways, including the xylose reductase/xylitol dehydrogenase (XR/XDH) and xylose isomerase (XI) pathways. The xylulokinase (XK) and the non-oxidative pentose phosphate pathway (PPP) were also overexpressed to facilitate pentose assimilation. The resulting strains, H131 -XYL 123 …