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Showing 1 to 3 of 3 for “"Aldol-Tishchenko reaction"”.
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Studies in asymmetric synthesis I the asymmetric alpha-alkylation of N,N-dimethylhydrazones II the synthesis of 1,3-amino alcohols via the aldol-Tishchenko reaction
… this moiety utilising t-butanesulfinimines in an aldol-Tishchenko reaction. Two and even three chiral centres can be installed simultaneously in one synthetic step, affording anti-1,3-amino alcohols in good diastereo-and enantioselectivity. To the best of our knowledge, no strategy involving …
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Studies in asymmetric synthesis: I. the asymmetric α-alkylation of N,N-dimethylhydrazones II. the asymmetric aldol-Tishchenko reaction of (S)-tert-butanesulfinyl imines for the introduction of 2, 3, 4 and 5 new chiral centres in one pot
… this system. This included examining a number of reaction parameters such as changing the chiral diamine, investigating different organolithium/(+)-sparteine and (+)-sparteine surrogate complexes and exploring different solvent combinations. The final section of this chapter examines the use of …
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New methods for the asymmetric synthesis of α-alkylated ketones and 1,3-amino alcohols
… 17 are observed. Chapter 4 introduces the first aldol-Tishchenko reaction of an imine derivative for the preparation of 1,3-aminoalcohol precursors. 1,3-Aminoalcohols can be synthesised via indirect routes involving various permutations of stepwise construction with asymmetric induction. Our …