Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Aldimines"”.
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New Strategies and Transformations for the alpha-Functionalization of Amines to Access Chiral Amines
… B6 transamination process: forming ketimines or aldimines to increase the acidities of alpha-C–H protons of amines, thereby enabling the alpha-C–H deprotonation accessible under mild reaction conditions for further derivation. Based on this known process mechanism, we first explored the umpolung …
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Sustainable catalysis using iron based catalysts for hydrofunctionalization of c=x (x = o, n) unsaturated bonds
… based iron complexes for the hydrosilylation of aldimines. Conversion of aldimines into amines is one of the most important chemical reactions in synthetic organic chemistry. Amines have been widely used for the production of bulk and fine chemicals, such as dyes, agrochemicals, pharmaceuticals, …
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Part I: Design, synthesis, and studies of novel age-inhibitors and age-breakers; Part II: Novel synthetic methods for organofluorine compound
… trifluoromethylation of aromatic N-tosyl aldimines with electron-withdrawing as well as electron-donating groups on the aryl ring. We have synthesized a series of novel purine-based triazole derivatives as potential CDK-inhibitors and characterized their structures using high-field …
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NATURAL PRODUCT INSPIRED METHODOLOGIES: ADVANCES IN DIASTEREOSELECTIVE N-SULFINYL IMINE AND TRIFLUOROPYRUVIC ACID REACTIONS
… worked well with a diverse set of N-sulfinyl aldimines and ketimines with 50-99% yield and 3:1 to 98:2 diastereoselectivity. A one-pot protocol was developed to access 1,2 amino alcohols with high diastereoselectivity. With a good understanding of the diastereoselective reaction with NSMD and …
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Simulating biochemical physics with computers
… for the decarboxylations of the external aldimines both in water and in DDC are calculated. The contributions of DDC to the rate enhancement of the reaction are elucidated. The reaction mechanism of L-dopa decarboxylation in DDC is proposed. The third part is to study the structural …
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Studies in asymmetric synthesis: I. the asymmetric α-alkylation of N,N-dimethylhydrazones II. the asymmetric aldol-Tishchenko reaction of (S)-tert-butanesulfinyl imines for the introduction of 2, 3, 4 and 5 new chiral centres in one pot
… A number of potential aldol acceptors including aldimines and a formaldehyde equivalent were examined. A challenging yet successful, scale-up of an aldol-Tishchenko reaction is also reported. The final section of this thesis describes the development of a remarkable novel methodology to …
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Development and application of carbon-carbon bond forming methodologies
… addition of carbon nucleophiles to prochiral aldimines was developed. This transformation capitalizes on the inherent properties of boron to promote a ligand exchange with chiral diols generating a chiral nucleophile in situ. Mechanistic studies were carried out to gamer a better understanding …
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Mirroring Enzymes: The Role of H-Bonding In HQuin-BAM Catalyzed Asymmetric Aza-Henry Reactions: A DFT Study into the Reactivity, Mechanism, and Origins of Selectivity
… addition to a range of electronically different aldimines, revealed that the origins of stereoselectivity were controlled by a delicate balance of different factors such as steric, orbital interactions, and the extent of distortion in the catalyst and substrates. The structural analysis of …
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Copper(I) Hydride-Catalyzed Transformations of π-Electrophiles
… detailed. Aromatic and aliphatic N-phosphinoyl aldimines possessing a variety of functional groups are coupled with both terminal and internal enynes under mild conditions. The resulting homopropargylic amines are produced in high yields, with moderate diastereoselectivities and generally high …
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METHODOLOGY DEVELOPMENT OF N-SULFINYL METALLOENAMINES AND ASYMMETRIC TOTAL SYNTHESIS OF (+)-EPIIBOGAMINE
… as a surrogate for poorly reacting N-sulfinyl aldimines in the DM3 reaction. This silyl-modified DM3 reaction enabled the shortest asymmetric total synthesis of (+)-epiibogamine in 7 steps. This isoquinuclidine intermediate would also provide access to (+)-dihydrocatharanthine and other Iboga …