Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Aldh2"”.
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Desarrollo de ribozimas de horquilla y martillo para disminuir la actividad de la deshidrogenasa aldehídica mitocondrial (ALDH2) de rata
… o protectores frente al alcoholismo. El gen ALDH2 eshabitualmente permisivo (alelo ALDH2*1) porque codifica la enzimadeshidrogenasa aldehídica mitocondrial la cual cataliza la oxidación delacetaldehído a acetato en la vía degradativa del etanol. Este gen tiene unsegundo alelo protector, …
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A small molecule-guided structure-function exploration of mitochondrial aldehyde dehydrogenase
… selected mitochondrial aldehyde dehydrogenase 2 (ALDH2) as a representative enzyme for small aldehyde metabolism. We subsequently identify one kudzu flower-derived isoflavone, kakkalide, that is able to enhance the activity of ALDH2, and we characterize the binding and kinetics of this …
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Investigation of Carbamathione Pharmacokinetics and Pharmacodynamics by In Vivo Microdialysis and Capillary Electrophoresis
… its inhibition of liver aldehyde dehydrogenase (ALDH2). Recent studies have reported that disulfiram exhibited an anti-craving effect with both alcohol addiction and cocaine dependence. Inhibition of ALDH2 cannot explain disulfiram's efficacy in cocaine dependence. The disulfiram metabolite S-(N, …
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Differential Na+/K+ Pump Isoform Expression in Higher and Lower Brain Regions of the Mouse
… α1 and α3 isoforms in the brains of Aldh2+/+ and Aldh2-/- mice across the lifespan, under both baseline (naïve) and chronic unpredictable stress (CUS) conditions. Quantitative polymerase chain reaction was used to analyze mRNA expression levels of α1 and α3 isoforms within higher and …
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Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… enhanced protein expression for ALDH1A1 (A549), ALDH2 (MCF7) and ALDH3A1 (A549). In contrast, the protein level was reduced for ALDH1A1 in HT29 cells after decitabine treatment. ALDH1A1, ALDH2 and ALDH3A1 were highly expressed in prostate cell lines, with expression linked to promoter …
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Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… enhanced protein expression for ALDH1A1 (A549), ALDH2 (MCF7) and ALDH3A1 (A549). In contrast, the protein level was reduced for ALDH1A1 in HT29 cells after decitabine treatment. ALDH1A1, ALDH2 and ALDH3A1 were highly expressed in prostate cell lines, with expression linked to promoter …
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Humane Alkoholdehydrogenasen und Aldehyddehydrogenasen : Bedeutung für den Metabolismus von Methylpyrenderivaten und von 5-(Hydroxymethyl)-2-furfural
… alle bekannten humanen ADH sowie die humanen ALDH2 und 3A1 (aus theoretischen Überlegungen heraus die vielversprechendsten Formen) für kinetische Analysen in Bakterien exprimiert. Als Enzymquelle dienten zytosolische Präparationen und durch Anionenaustauschchromatographie partiell gereinigte …
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Mechanisms Underlying Alcohol-Mediated Cellular Injury In Esophageal Keratinocytes
… of AMPK and inhibition of mTORC1. Loss of ALDH2 increased the susceptibility of esophageal keratinocytes to alcohol and acetaldehyde mediated toxicity and cell death. Cells were more reliant on autophagy in the absence of ALDH2 to negate alcohol-induced oxidative stress and DNA damage. In …
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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
… (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds.
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Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… cancer. This study showed that ALDH1A3, ALDH1B1, ALDH2 and ALDH7A1 are highly expressed in primary prostate cancer cells (n=9) compared to benign (n=9) prostate cells. The expression of ALDH1A3 was high in the stem cells (SCs) (n=3) as well as the more differentiated counterparts (n=16). Treatment …
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Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… cancer. This study showed that ALDH1A3, ALDH1B1, ALDH2 and ALDH7A1 are highly expressed in primary prostate cancer cells (n=9) compared to benign (n=9) prostate cells. The expression of ALDH1A3 was high in the stem cells (SCs) (n=3) as well as the more differentiated counterparts (n=16). Treatment …