Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"Alcohol exposure"”.
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Parietal dysfunction in children with prenatal alcohol exposure
… be one of the regions most affected by prenatal alcohol exposure. Functional domains dependent on intact parietal functioning, including mathematical and visuospatial ability, have been consistently implicated in fetal alcohol spectrum disorders. This thesis examines, in children, using blood …
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Playfulness and prenatal alcohol exposure : a comparative study
Includes abstract. Includes bibliographical references.
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Effects of Early Alcohol Exposure on Ocular Dominance Plasticity
Fetal alcohol spectrum disorder is the leading cause of mental retardation in the western world. It is associated with learning and sensory deficits. Some of these deficits are a result of faulty neuronal plasticity. Previously our lab has used ferrets to demonstrate that alcohol exposure during …
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Thiamine deficiency and alcohol exposure both lead to an impulsive phenotype
<p>The detrimental effects of alcohol consumption, including impulsivity, cognitive inflexibility, and neuropathology, are due to a confluence of factors that often occur in addition to alcoholism. We examined the effects of chronic alcohol exposure and thiamine deficiency (or supplementation) in …
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Profiling the neurovascular cell interactions in alcohol exposure and HIV-1 infection
Alcohol use is known to exacerbate the progression of human immunodeficiency virus associated acquired immunodeficiency syndrome or HIV/AIDS in the brain, known as the NeuroAIDS. The mechanisms of this accelerated progression are still poorly understood. The purpose of my thesis is to review the …
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Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
<p>Excessive alcohol consumption is associated with increased fracture risk, delayed bone healing and fracture non-union. Binge alcohol consumption has occurred in 25-40% of all orthopaedic trauma cases. The canonical Wnt pathway, through tight regulation of stabilized beta-catenin, plays an …
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Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study
Years of research have demonstrated that prenatal exposure to alcohol contributes to a range of effects in exposed children. These include problems in attention and hyperactivity, deficits in memory and learning, and problems with social, as well as emotional development. Past research has …
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Prenatal alcohol exposure-related reading and phonological processing deficits mediated by working memory
… have investigated the effects of prenatal alcohol exposure (PAE) on reading ability and/or on phonological processing. Most published studies have only included measures of single-word reading. This choice means those studies may lack ecological validity in that they might not have …
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The Effect of Embryonic Alcohol Exposure on Brain Function and Behavior in Zebrafish Strains
The biological mechanisms that underlie fetal alcohol spectrum disorder (FASD) are complex and poorly understood. This thesis aims to investigate potential underlying mechanisms of FASD by using zebrafish as a model organism. The research question asked is how does embryonic alcohol exposure alter …
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Effects of Acute Alcohol Exposure on Post Burn Intestinal Immunity: Role of IL-23
… of these injuries occur under the influence of alcohol/ethanol (EtOH) intoxication. Burn victims who sustain injury under the influence of EtOH exhibit significantly higher rates of morbidity and mortality than patients without EtOH exposure at the time of injury. Several lines of evidence …
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Neuroimaging study of prenatal alcohol exposure effects on structural and functional connectivity in children
Fetal alcohol spectrum disorders (FASD) describe the spectrum of cognitive, behavioural and neurological impairments associated with prenatal alcohol exposure (PAE). Diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI) were used to assess effects of PAE on microstructural …
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The effect of acute alcohol exposure on hepatic oxidative stress and function: prevention by micronutrients
Alcohol binge drinking, especially in teenagers and young adults is a major public health issue in the UK, with the number of alcohol related liver disorders steadily increasing. Understanding the mechanisms behind liver disease arising from binge-drinking and finding ways to prevent such damage …
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Quantifying the Effect of Vitamin D Deficiency and Alcohol Exposure on Immune Response to Mycobacterium Infection
… conjunction with adolescent immune response and alcohol exposure. This research will provide insight into the ramifications of age-related vitamin D3 deficiency and its effect on the outcome of mycobacterium infection, as well as, the combined effects of vitamin D3 deficiency and alcohol exposure …
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Differences in callosal and subcortical volumes and associated neurobehavioural deficits in children with prenatal alcohol exposure
… of South Africa where heavy maternal prenatal alcohol consumption is perpetuated by historical and societal challenges, have some of the highest prevalence rates of fetal alcohol syndrome (FAS) in the world. FAS has lifelong behavioural and cognitive consequences. Neuroimaging research aims to …
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Effects of prenatal alcohol exposure on pup development and vocalization behavior and on dam retrieval behavior
… to study the effects of chronic prenatal alcohol exposure on pup development and on the functional efficacy of pup vocalizations on the maternal behavior of the dam. Subjects were 72 dams and their litters. Dams were matched by weight and assigned to either an Ethanol (EtOH), a Pair-fed …
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The Long-Term Teratogenic Effect of Prenatal Alcohol Exposure on the Somatosensory and Motor Cortex of Rats
… was to examine the long-term effect of prenatal alcohol exposure (PAE) on the primary somatosensory (SI) and primary motor cortex (MI). For over 30 years, PAE has been shown to produce a triad of symptoms (growth deficits, craniofacial dysmorphologies and central nervous system disruptions) …
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Development of the adolescent prefrontal cortex and basolateral amygdala and the effects of puberty and alcohol exposure
… change,adolescent rats were exposed to alcohol in a binge-like manner and then sacrificed in adulthood to quantify the number of neurons and glia. Results reported in chapter 4 revealed no significant differences in the total number of neurons in the mPFC. However there was a significant …
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Prenatal alcohol exposure and the early neurodevelopmental outcomes of children in a South African birth cohort study
Introduction: Over the last few decades, prenatal alcohol exposure (PAE) has been a major public health problem both globally and in low- to-middle-income countries (LMICs) such as South Africa. Pregnant women and new mothers are particularly vulnerable; and PAE may be associated with adverse child …
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Neuroendocrine Consequences of Binge Alcohol Exposure During Peri-Puberty on Functioning of the Hypothalamo-Pituitary-Adrenal (HPA) Axis
<p>Binge alcohol (EtOH) exposure in adolescence is a fundamental health concern. In 2005, over 20% of teenagers between ages 15 and 17 reported binge drinking behavior within a one month period preceding the survey (Dept. of Health and Human Services: Substance Abuse and Mental Health Services …
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Impact of Prenatal Alcohol Exposure on Cognition and Inflammation in Aging Male and Female Rats: A Longitudinal Approach
Prenatal alcohol exposure (PAE) is a serious global health concern that can have long-lasting detrimental effects on the developing brain and behaviour. However, less is known about the effects of PAE as an individual ages into middle and old age. Here, we investigate the long-term effects of PAE …
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