Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Alarmone"”.
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Structural and Functional Studies on the Escherichia coli Inducible Lysine Decarboxylase: Linking the Acid Stress and Stringent Responses
… co-crystallized with the stringent response alarmone ppGpp. The stringent response is activated under nutritional and stress conditions and reorganizes cellular transcription and metabolism from exponential-phase growth into stationary phase growth. The primary target of ppGpp is the RNA …
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Characterization of beneficial mutations in unsaturated fatty acid biosynthesis that are recurrent dead-ends in a long-term evolution experiment with Escherichia coli
… global repressor SpoT to produce the cellular "alarmone" (p)ppGpp, inhibiting cell growth during the stringent response. Thus, it is possible that fabR mutations that prolong fatty acid synthesis and spoT mutations that alter the production of (p)ppGpp may both benefit cells by affecting the …
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Characterization of Bacterial Transcriptional Regulatory Networks through Genome-Wide in vitro Run-Off Transcription RNA-Seq (ROSE)
… in E. coli K-12 MG1655. The protein DksA and the alarmone ppGpp were added to extend the ROSE method, resulting in 2,205 TSS with differential transcription activity of at least twofold in the presence of DksA+ppGpp. Out of these, 1,387 TSS showed a positive regulation, and 818 TSS showed a …
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Cryo-EM Studies of Bacterial RNA Polymerase
… This global response depends on two factors, the alarmone ppGpp, and the transcription factor DksA. Unlike most transcription factors, ppGpp and DksA bind directly to RNAP but not to DNA. Another transcription factor, TraR, regulates RNAP the same way as ppGpp and DksA. TraR, and ppGpp/DksA, can …