Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Alanine residue"”.
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Crystallographic studies on enzymatic halogenation of natural products
… L-Trp binding sites and identify the conserved residue Lys79 as a likely candidate for covalent modification to produce an enzyme-bound lysine chloramine intermediate. A lysine chloramine at this position would direct the chlorination reaction to the correct site on the substrate, which could …
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Experimental characterization of polyalanine helices in short and long contexts
… determine the intrinsic helical propensity of an alanine residue, free from the hydrophobic packing within proteins. Constructed cross checks between these methods add rigor to propensity assignments and present the opportunity to resolve controversies regarding helical propensities and limiting …
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Total synthesis of naturally occurring glycosylated tetramic acids
… an aminolysis reaction to install the L-alanine residue, followed by a Lacey-Dieckman cyclisation. The 7S stereocenter was established using a rhodium based homogeneous catalyst and applying a high-pressure hydrogenation to the tetramic acid. Stable BF2-chelate complexes are here utilized …
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Reengineering Estrogen Receptor Hormone Specificity Through Coordinated Changes at Key Contact Sites Between Estrogen Receptor and Estradiol
… at which portions of the ligand contact specific residues in its receptor. In the nuclear hormone receptors, mutational mapping studies, and more recently, X-ray structures, provide information on these key, specificity-defining contact sites. Based on this information, we have made a series of …
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Homoglutathione Synthetase And The Plant Thiol-Redox Proteome
… is a GSH analog that contains a terminal beta-alanine residue instead of a terminal glycine. This alternate reaction is catalyzed by hGSH synthetase, which is related to GSH synthetase; however, the specific features that alter substrate specificity are unknown. To understand the molecular …
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Studies on the Structure of Human Fibronectin
… chloride technique. No NH<sub>2</sub>-terminal residue was detected in either the intact molecule or the small fragment, whereas analysis of the large fragments yielded dansyl-alanine. Treatment of the intact molecule and the small fragment with L-pyroglutamyl-peptide hydrolase resulted in the …
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Detailed Characterization of Structure-Activity Relationships in the Human Adiponectin Molecule
… (HexNAc-Hex) and up to five sialic acid (Sia) residues were thus identified in enzyme-digested peptides derived from the NH2-terminal region: these were similar to the O-linked HexNAc-Hex-Sia chains that are typically present in mucin-like glycoproteins. These Olinked modification sites were …