Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Akt2"”.
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Akt2 Redox-regulation in Breast Cancer and Diabetes
… The three mammalian isoforms of Akt (Akt1, Akt2, and Akt3) share common structural and functional characteristics. Despite their common features and shared activation pathway, the Akt isoforms exhibit divergent regulation of downstream processes. The molecular basis for these differences is …
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Molecular and Functional Regulation of Akt2 by Oxidation
… the linker region cysteine, Cys124, in the Akt2 kinase as a target of PDGF-stimulated oxidation. In vitro studies shown here demonstrate selective inactivation of the Akt2 isoform following direct oxidation with H<sub>2</sub>O<sub>2</sub> which is shown to occur through a reversible …
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The Role of Akt2 in Hepatic Lipid Metabolism
… Previous studies have demonstrated that Akt2 is critical to insulin’s control of glucose metabolism, but its role in lipid metabolism has remained controversial. Here we show that Akt2 is required for hepatic lipid accumulation in obese, insulin-resistant states induced by either …
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Biophysikalische Untersuchung von Phloem-lokalisierten Carriern und Kaliumkanälen und deren Interaktion im Modellsystem der Xenopus Oozyte
… zum Saccharosetransport in der Arabidopsis akt2/3-1 Mutante. Das AKT2/3 Gen kodiert für einen Phloem-spezifischen Kaliumkanal vom Shaker-Typ. Die Tatsache, dass der Saccharosegehalt im Phloem dieser Mutante um 50% im Vergleich zum Wildtyp reduziert war, ließ eine enge Kopplung von Kalium- …
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K+-Homöostase und kaliumabhängige Xylogenese in Populus tremula L. x Populus tremuloides Michx
… anhand der abgeleiteten Aminosäuresequenz der AKT2/3-Unterfamilie und KPT1 dem KAT1-Subtyp der Shaker-Familie zuordnen, während sich PtKUP1 in die Familie der KT/KUP/HAK-Transporter einreihte. Ein direkter Zusammenhang zwischen Kaliumtransport und holzbildenden Zellen konnte durch Verringerung …
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Molecular Mechanism of Aurora-A Kinase in Human Oncogenesis
… protein. CNTD2 locates to chromosome 19q13.2 AKT2 amplicon. CNTD2 is amplified and overexpressed in human ovarian, pancreatic and lung cancer cell lines and primary tumors. CNTD2 colocalizes and interacts with Aurora-A in the centrosome. CNTD2 expression induces Aurora-A and cdc2 kinase …
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Molecular Mechanisms of Hepatitis C Virus- Associated Steatosis
… was also able to increase activity of Akt 1 and Akt2; inhibition of Akt activity resulted in decreased SREBP-1 activity thereby indicating that HCV core partially mediates SREBP-1 via Akt. Further experiments examined the role of another HCV protein, NS2, in these same lipid metabolism pathways. …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… kinase isoforms have been identified viz AKT1, AKT2 and AKT3 and elevated AKT1 and AKT2 kinase activity has been reported in 30-40% of oestrogen receptor-positive breast carcinomas. Given the overlapping oncogenic roles between AKT and TBX3 in breast cancer, and because TBX3 has previously been …
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THE EFFECT OF FLAXSEED AND ITS LIGNAN COMPONENT ON ESTROGEN SIGNALING AND METABOLISM IN NORMAL AND CANCEROUS HEN OVARIES
… defatted flax meal and flax oil decreased AKT2 mRNA expression but did not affect its activation. Another major regulator of intracellular signaling, ERK 1/2 MAPK appeared to be upregulated in tumors from flaxseed fed hens. Whole flaxseed diet was also significant in altering the metabolism …