Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Akt1"”.
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Die Rolle von Kaliumkanälen der AKT1-Unterfamilie für Kaliumaufnahme und gerichtetes Wachstum
… sativa-Keimlingsgewebe konnte das cDNA-Molekül OsAKT1 isoliert und anhand der abgeleiteten Aminosäuresequenz der AKT1-Unterfamilie des Shaker- Typs pflanzlicher Kaliumkanäle zugeordnet werden. vi. Die Transkripte von OsAKT1 wurden in Koleoptile und Wurzel 5 Tage alter Reiskeimlinge lokalisiert. Im …
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Mdm2-Mediated Degradation of Sirt6 Phosphorylated By Akt1 Promotes Tumorigenesis and Trastuzumab Resistance In Breast Cancer
… towards cancer treatment. Here, we show that AKT1 phosphorylates SIRT6 at Ser<sup>338</sup> and induces MDM2-SIRT6 interaction, priming SIRT6 for degradation via the MDM2-dependent ubiquitin-proteasome pathway. Blocking SIRT6 Ser<sup>338</sup> phosphorylation prevents its degradation by MDM2 …
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Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
Akt1 (protein kinase B), a serine/threonine kinase, has emerged as a critical molecule in signal transduction pathways involved in cell proliferation, growth, survival, apoptosis and glucose metabolism. A previous study has shown that transplanted human neural stem cells (hNSCs) selectively migrate …
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PREPARATION AND EVALUATION OF DECONSTRUCTION ANALOGS OF 7-DEOXYKALAFUNGIN AS AKT INHIBITORS
… features of the compounds necessary to inhibit AKT1 potently and selectively were determined. It was observed that compounds with a pyran ring were more potent in inhibiting AKT1. Conversely, flexible compounds were found to be weak inhibitors of AKT1. Also, presence of a lactone ring was found …
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Combined Inhibition of Ddr1 and Cdk4/6 Induces Synergistic Effects In Er-Positive, Her2-Negative Breast Cancer With Pik3Ca/Akt1 Mutations
… HER2-NEGATIVE BREAST CANCER WITH <em>PIK3CA/AKT1</em> MUTATIONS</strong></p> <p>Maryam Shariati, M.S. Advisory Professor: Funda Meric-Bernstam, M.D.</p> <p>Molecular alterations in the phosphatidylinositol 3‑kinase (PI3K)/ serine/threonine protein kinase B (AKT) signaling pathway occur …
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Unterschiedliche Aktivierung von Signalwegen zur Zellproliferation in mesenchymalen Tumoren des Gastrointestinaltrakts
… Expression ausgewählter Signaltransduktions- (AKT1/ERK2) und Zellzyklus-Proteine wurde quantitativ mittels immunhistochemischer Färbungen an tissue microarrays von 137 GIST, 15 Leiomyomen und 11 Leiomyosarkomen bestimmt. KIT-Expression wurde ausschließlich in GISTgefunden, während …
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Presynaptic signalling in Huntington’s disease
… dysregulation of phospho-Dyn1 or phospho-GSK3. Akt1, which is known to be dysregulated in HD, is another downstream member of the BDNF signalling pathway involved in regulating ADBE. Previous work showed that Akt1, which phosphorylates Htt at serine residue 421 (Htt S421), exhibits decreased …
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Πραγματικά δεδομένα σχετικά με τις μεταλλάξεις Pi3k σε ασθενείς με μεταστατικό HR(+), HER2(-) καρκίνο του μαστού: ανασκόπηση της βιβλιογραφίας από ένα μόνο κέντρο σχετικά με την αποτελεσματικότητα του inavolisib/capivasertib / Real world data regarding Pi3k mutations in metastatic HR(+), HER2(-) BC patients: a single center experience review of literature regarding the efficacy of inavolisib/capivasertib
Το μονοπάτι σηματοδότησης PIK3CA/AKT1/PTEN διαδραματίζει καθοριστικό ρόλο στον κυτταρικό πολλαπλασιασμό, τον μεταβολισμό, την επιβίωση και την απόπτωση. Σε ασθενείς με HR+/HER2- καρκίνο του μαστού αποτελεί το συχνότερα απορρυθμισμένο σηματοδοτικό μονοπάτι και έχει συσχετιστεί με την ανάπτυξη …
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Molecular Regulation of Direct Cardiac Reprogramming
… beating after 3 weeks of induction by AKT1 plus GHMT (AGHMT). Furthermore, AGHMT evoked a more mature cardiac phenotype for iCMs, as seen by enhanced polynucleation, cellular hypertrophy, gene expression, and metabolic reprogramming. Insulin-like growth factor 1 (IGF1) and …
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Improving salt stress resistance in cereals
… lines overexpressing OsTPKa, OsTPKb and OsAKT1 were generated using Agrobacterium mediated rice transformation, while for OsAKT1 a loss of function mutant was also isolated. Transgenic and mutant plants were characterized to study the role of these genes in rice. For barley, transgenic …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… kinase isoforms have been identified viz AKT1, AKT2 and AKT3 and elevated AKT1 and AKT2 kinase activity has been reported in 30-40% of oestrogen receptor-positive breast carcinomas. Given the overlapping oncogenic roles between AKT and TBX3 in breast cancer, and because TBX3 has previously …
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Investigations on the Effects of Palmitate on Neuronal Cells
… insulin for 0, 5, or 10 minutes. Activation of AKT1 and GSK-3β was then analyzed by Western blot assay. Preliminary results suggested that while insulin-induced GSK-3β activation may not be affected by PA treatment, insulin-induced AKT1 activation appeared to be attenuated by PA treatment as …
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Integrating Functional Genomics with Systems Biology to Discover Drivers and Therapeutic Targets of Human Malignancies
… disease contexts. For example, I discovered that AKT1 is a driver for glucocorticoid (GC) resistance, a problem in the treatment of T-ALL. The inhibition of AKT1 was validated to reverse GC-resistance. Additionally, upon silencing predicted master regulators of GC resistance with shRNA screens, 13 …
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The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study
… nucleotide polymorphisms (SNPs) within GSK3B, AKT1, ARRB2, GRIA2 and PPPARGC1A could be associated with the incidence and severity of lithium-induced side effects.
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Akt2 Redox-regulation in Breast Cancer and Diabetes
… processes. The three mammalian isoforms of Akt (Akt1, Akt2, and Akt3) share common structural and functional characteristics. Despite their common features and shared activation pathway, the Akt isoforms exhibit divergent regulation of downstream processes. The molecular basis for these …
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Yap1 Expression Predicts Sensitivity to Dual Akt/P70S6K Inhibition In Ovarian and Uterine Malignancies
… of MSC2363318A, which is a novel inhibitor of AKT1, AKT3, and P70S6K.</p> <p><strong>Experimental Design: </strong>Orthotopic murine models of ovarian and uterine cancer were utilized to study the effect of MSC2363318A on survival and regression. Moreover, <em>in vitro</em> experiments (MTT, …
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Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
… activity of three PI3K/AKT/mTOR pathway members: AKT1, p70S6K and 4E-BP1) in a variety of contexts, including under baseline cell growth conditions and in response to treatment with different PI3K/AKT/mTOR pathway inhibitors. Traditional genetic analyses were used to identify pathway activation …
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Molecular and Functional Regulation of Akt2 by Oxidation
… suggested to allow for distinct regulation of Akt1 and Akt2 signaling in the NIH 3T3 cells. The role of NOX-derived and mitochondrial-based ROS in regulating Akt2 activity following PDGF stimulation is also elucidated. Finally, functional consequence of Cys124 oxidation on modulating …
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Identification of a ciliary defect associated with pulmonary nontuberculous mycobacterial disease
… PKC. Inhibition of the PI-3K pathway (PI-3K , Akt1, and PDK1) closely mimicked the ex vivo phenotype seen in PNTM patient respiratory epithelia. These data identify a novel aspect of PNTM disease with in vivo and ex vivo correlates that suggest that PNTM infection is associated with abnormal …
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Genetic association between schizophrenia and type-2 diabetes
… v-akt murine thymoma viral oncogene homolog 1 (AKT1). The Haploview™ program was applied to check Mendelian errors, to test Hardy-Weinberg equilibrium (HWE) and to estimate linkage disequilibrium (LD) between paired SNPs. Analysis for allelic and haplotypic associations and for the gene-gene …
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