Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Akt signalling"”.
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The role of VEGF-induced PI3K/Akt signalling pathway in head and neck cancer cell migration
The PI3K-Akt signalling pathway is a well-established driver of cancer progression. One key process promoted by Akt phosphorylation is tumour cell motility; however the mechanism of VEGF-induced Akt phosphorylation leading to motility remains poorly understood. Previously, it has been shown that …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
… pro-survival, neuroprotective and anti-stress signalling functions. Autosomal recessive mutations in PINK1, resulting in a loss of PINK1 function, cause early onset Parkinson’s disease (PD). This thesis aimed to investigate the mechanisms by which PINK1 protects against PD, with a focus on …
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A Role for the Phosphoinositide Lipid Kinase PI4KIIIbeta in Breast Oncogenesis and Akt Activation
… We found that PI4KIIIβ expression activates Akt kinase in the BT549 breast cancer cell line. PI4KIIIβ overexpression led to an increase in the plasma membrane abundance of the PI3K derived PI(3,4,5)P3/PI(3,4)P2 lipids, upstream activators of Akt signalling. PI(4)P and PI(4,5)P2 are precursors …
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Novel Insights into the Regulation and Function of SGK3
Derailment of PI3K-Akt signalling is frequently implicated in cancer. While Akt is a highly studied kinase, comparatively little is known about serum and glucocorticoid activated kinase 3 (SGK3), which has similar substrate specificity to Akt and is also involved in growth and survival pathways. …
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INTERPLAY BETWEEN MDM2 AND TFAM REGULATES OXIDATIVE PHOSPHORYLATION IN DRUG-RESISTANT ONCOGENE-ADDICTED CANCERS
… Furthermore, we describe an increase in AKT signalling in TKI-resistant cancers that contributed to protein stability of MDM2 through phosphorylation. Inhibition of AKT leads to decrease in MDM2 Ser166 phosphorylation and increase mitochondria localisation in TKI-resistant cells. …
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Identifying the signalling pathway of a novel Myostatin Splice Variant (MSV)
… activated protein kinase (MAPK) and the PI3K/AKT signal transduction cascades. The discovery in our laboratory of a novel splice variant of Mstn (MSV) that opposes Mstn and stimulates the proliferation of myoblasts provided the impetus for the investigations in this thesis. The splicing of MSV …
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Modulation of innate immune responses in nasopharyngeal epithelial cells by the Epstein-Barr virus (EBV)-encoded latent membrane proteins LMP2A and LMP2B
… B-cell receptor in B-cells, preventing BCR signalling and ensuring viral latency. Much less is known about the function of these proteins in epithelial cells, although LMP2A has been shown to modulate Wnt/\(\beta\)-catenin, MAPK and PI3K/Akt signalling, whilst LMP2A and LMP2B have been shown …
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Pharmacological activation of pro-survival pathways as a strategy for improving donor heart preservation
… by the activation of endogenous pro-survival signalling pathways by the addition of pharmacological agents to Celsior, a clinical preservation solution. Studies were conducted in an isolated working rat heart model of donor heart preservation. The first study investigated the cardioprotective …
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Neuroprotective effects of incretin mimetics upon chronic endoplasmic reticulum (ER) stress : implications for novel therapeutic pathways and opportunities in Alzheimer's disease
… effects of Liraglutide along with the signalling network against the persistent and calcium-dependent ER stress in the human proliferating SH-SY5Y neuroblastoma cells. I report that Liraglutide modulated the ER stress response and elicited ER proteostasis and autophagy machinery …
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SGK3 activity and regulation in PI3K-Akt pathway inhibitor resistance in breast cancer
The PI3K-Akt signalling pathway is central to cell proliferation and growth, and hyperactivating mutations in this pathway are found in a large number of cancers. Downstream of PI3K, Akt is heavily studied, however the highly related SGK family of protein kinases have recently been identified as …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… activates TBX3 in breast cancer cells. The AKT signalling pathway has been shown to contribute to uncontrolled proliferation, invasion and metastasis of breast cancer leading to poor prognosis. Three AKT serine-threonine kinase isoforms have been identified viz AKT1, AKT2 and AKT3 and …
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Investigating the role of R2TP-like co-chaperone complexes during axonemal dynein assembly
… and potentially Heatr2) in the regulation of AKT signalling and therefore impact cell proliferation.
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Suppression and activation of lipid signalling in cancer : tumour suppressor PTEN and oncogenic sphingosine kinase
… phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway to modulate cell proliferation, cell cycle progression and cell survival. Sphingosine kinase 1 (SphK1), a known tumour promoter/oncogene, has been shown to activate the PI3K/Akt pathway to enhance resistance to apoptosis. The …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… but repressed by the P1(3,4,5)P<sub>3</sub>/PDK1/AKT signalling pathway. Interestingly FOXO1 is not regulated by glucose or amino acid availability in CTL, which are essential regulators of CTL growth, proliferation and effector function. <br/><br/>Using FOXO1<sup>GFPflx/GFPflx</sup> Granzyme B …
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Akt signal transduction dysfunction in the 3xTg-AD mouse model of Alzheimer's disease
… IGF-1R) are the primary activators of PI3- K/Akt through which they regulate cell growth, development, glucose metabolism, and learning and memory. Work in our lab and others shows increased Akt activity and phosphorylation of its downstream targets in AD brain, along with insulin and …
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Perineural Invasion in Oral Squamous Cell Carcinoma and Salivary Gland Malignancies: Incidence, Prognostic Impact and Molecular Insight
… as being possibly of importance in PNI. The PI3K/Akt signalling pathway is a well-established driver of cancer progression, however, the mechanism of NGF-induced Akt phosphorylation remains unclear. Identifying the molecular background of PNI-driven OSCC and SGMs will shed light on the underlying …
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Einfluss von Celecoxib auf die Entstehung und den Verlauf einer kardialen Hypertrophie
… deutlichen Anstieg der Phosphorylierung von Akt verbunden. In verschiedenen anderen Geweben konnte bereits gezeigt werden, dass der selektive Cyclooxygenase (COX)-2 Hemmer Celecoxib den Akt-Signalweg beeinflussen kann. Wir untersuchten den Effekt von Celecoxib auf den Akt-Signalweg in …
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A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
… and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of effector proteins involved in regulation of cell migration, metabolism and growth. The importance of this network is evidenced by the relatively high …