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Showing 1 to 1 of 1 for “"Akt,ROS,phosphorylation,oxidation,PP2A"”.
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Redox Regulation of Akt Phosphorylation in PTEN-/- Mouse Embryonic Fibroblasts
… role of O2.- in regulating the survival kinase Akt via an oxidative inhibition of PTEN by S-nitrosylation. During the course of this study, it was noticed that in mouse embryonic fibroblasts that do not express the tumour suppressor PTEN (MEFPTEN-/- cells), a decrease in the intracellular level …