Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Airway hyperreactivity"”.
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Studies on the role of the autonomic nervous system in airway hyperreactivity.
The airway hyperreactivity (AH) characteristic of bronchial asthma has many possible underlying causes. This study focussed on the contribution of K+ -ion channels and Ca2+ - dependent processes to AH, in a guinea-pig model of asthma. Cromakalim, a potassium channel opening drug, attenuated …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… Allergic asthma is clinically characterized by airway hyperreactivity (AHR), increased mucus production and airway remodeling. On the cellular level, pulmonary eosinophilic infiltration and augmented levels of serum IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… Allergic asthma is clinically characterized by airway hyperreactivity (AHR), increased mucus production and airway remodeling. On the cellular level, pulmonary eosinophilic infiltration and augmented levels of serum IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway …
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The temporal requirement of IL-4Rα signalling in allergic asthma and the role of IL-4Rα-responsive Regulatory T cells in restraining allergic airway inflammation
Allergic asthma is a chronic inflammatory airway disease driven predominantly by a TH2 immune response to environmental allergens. The asthma pathology is predominantly elicited by IL-4 and IL-13 signalling via IL-4Rα-signalling which is essential for driving TH2-type immunity to allergens. …
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New Mediators and Novel Mechanisms in Allergic Airway Inflammation
… involved in the allergic response can induce airway hyperreactivity by affecting the airway smooth muscle directly and to identify novel mediators involved in allergic airway inflammation. The effect of the pro-inflammatory cytokine interleukin (IL)-4 on airway smooth muscle contractions was …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
… including inhibition of allergen-induced IgE, airway hyperreactivity (AHR), inflammatory cells, and mucus-producing goblet cells. When rapamycin was administered after systemic sensitization, but just prior to allergen exposure to the lung, many key responses including increases in IgE, AHR, …
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis
… million people and is characterized by chronic airway inflammation, reversible airflow limitation, and airway hyperreactivity. AD is affecting approximately 15%-20% of the pediatric population and 7%-10% of adults in the world and is characterized by dysregulation of skin barrier and immunity, …
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Nerve growth factor regulates Na+ transport in human airway epithelial cells
… between elevated NGF levels in the lung and airway diseases, including lung inflammatory diseases and respiratory virus infections. NGF can be produced and act upon both structural and non-structural cells of the airways, and overexpression of NGF causes morphological and physiological …