Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Airway Surface Liquid"”.
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DEVELOPMENT AND TESTING OF A FLEXIBLE PLASTIC HYDROGEN ION-SELECTIVE ELECTRODE FOR IN VIVO pH MEASUREMENTS OF AIRWAY SURFACE LIQUID
… impair chloride and bicarbonate transport to the airway lumen, leading to mucus thickening and acidification of the airway surface liquid (ASL). These alterations impair host-defence, making CF patients more prone to recurrent microbial infections in the respiratory tract. This project aimed to …
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Novel endoscopes for microscopic assessment of airway clearance using micro-optical coherence tomography
… human respiratory system depends critically on airway clearance via motile hair-like structures (cilia), which transport and eliminate unwanted particles trapped within mucus. Impairment of mucociliary clearance (MCC) can lead to life-threatening airway narrowing and lung infections, and is a …
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Nebulized Hypertonic Saline-Triggered Increase in Mucociliary Clearance Rate is Mediated by the Nervous System
… functions, in part, to increase the volume of airway surface liquid (ASL) by generating an osmotic gradient that draws water into the airway lumen and, thus, increasing mucociliary clearance (MCC). However, recent research has also demonstrated that HTS-triggered increase in ASL height is …
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LIPID-BASED APPROACHES TO OPTIMIZE THE EFFECTIVENESS OF INNOVATIVE DRUG MODULATORS IN CYSTIC FIBROSIS
… system, with impaired mucociliary clearance and airway surface liquid dehydration, leading to recurrent infections and high morbidity. The most common mutation, the deletion of phenylalanine at position 508 (F508del), induces misfolding and retention of CFTR in the endoplasmic reticulum, causing …
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Amphotericin B ion channels restore cystic fibrosis airway surface physiology
… apical bicarbonate transport and decreased airway surface liquid (ASL) pH, which impairs respiratory host defenses and leads to chronic lung infections. Because basolateral pumps and channels remain active in the absence of functional CFTR, we hypothesized that an outward-facing bicarbonate …
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Modeling the Mechanical Effects of Liquid Mediated Adhesion Between the Human Vocal Folds
… of the vocal folds results in the formation of a liquid bridge. The adhesion equation was validated using experimental data, and simplified to a one-dimensional approximation with an included correction factor that adjusted the predicted pressure in situations where the one-dimensional …
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Nerve growth factor regulates Na+ transport in human airway epithelial cells
… between elevated NGF levels in the lung and airway diseases, including lung inflammatory diseases and respiratory virus infections. NGF can be produced and act upon both structural and non-structural cells of the airways, and overexpression of NGF causes morphological and physiological …
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Understanding and predicting acute pulmonary exacerbations in adults with cystic fibrosis
… viscid mucus, depletion and acidification of the airway surface liquid and impairment of the normal muco-ciliary clearance mechanisms, providing a permissive environment for chronic infection and progressive airway damage. Pseudomonas aeruginosa is a versatile, Gram-negative opportunistic human …
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Small molecule channels increase anion secretion and host defenses in cystic fibrosis airway epithelia: mechanistic studies and initial clinical translation
… of CFTR-mediated HCO3- and Cl- secretion to the airway surface liquid (ASL) compromises airway host defenses in people with CF and contributes to the chronic bacterial infection and airway inflammation that characterize CF lung disease. Major clinical advances have been achieved with small …
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Understanding and predicting pulmonary exacerbations in Cystic Fibrosis using Machine Learning
… to a reduced depth to, and acidification of, the airway surface liquid, a sticky and viscous outer mucous layer, and impaired mucociliary clearance. This in turn leads to airway obstruction and chronic bacterial infection. Recurring, sudden, clinical deteriorations in respiratory symptoms - termed …
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Extraction and Biochemical Characterization of Alligator mississippiensis glycosaminoglycans and an Ex-vivo Murine Pilot Study to Test their Potential Effect on a Selected Panel of Genes Associated with Cystic Fibrosis
… a median survival age of 40.7 years. Chronic airway inflammation and dehydration are critical features of CF. The size and structure-dependent hydration and anti-inflammatory properties of glycosaminoglycans (GAGs) such as hyaluronic acid (HA) may help ameliorate these symptoms. The GAGs …