Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Airway Remodeling"”.
-
Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.
… asthma, a chronic inflammatory disease of the airways, show pathological changes in the airways, including airway remodeling, basement membrane thickening, and epithelial damage with large immune cell infiltrate. How the epithelium contributes to airway remodeling and subepithelial fibrosis is …
-
Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts
… proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung function causing a thickening of the airways. An increased ECM production of proteoglycans, collagens and other ECM molecules, usually accompanied …
-
Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation
… not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered difficult to …
-
TRAIL and TGF-ßl-Induced Apoptosis of Human Airway Epithelial Cells
… a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), airway obstruction, wheezing, and leads to airway remodeling if these symptoms persist. Airway remodeling is characterized by goblet hyperplasia, airway smooth muscle hypertrophy and hyperplasia, subepithelial …
-
TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
Asthma is a chronic disease of the airways characterized by airway hyperresponsiveness, airway inflammation, and airway remodeling. Eosinophils migrate to the airways and play a significant role in the pathogenesis of asthma, particularly through their release of mediators and cytokines. …
-
Mechanotransduction via airway epithelial cells : the effect of compressive stress
… a change in the structural organization of the airway epithelium. This complex process known as airway remodeling is not fully understood, and we believe that the forces accompanying airway constriction activate the epithelium and contribute to airway remodeling. To better understand this …
-
Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells
… cardinal features of asthma is the presence of airway remodeling, the structural changes that contribute to exaggerated narrowing of the airway. Fibroblast-to-myofibroblast transition (FMT) is an airway remodeling phenomenon whereby fibroblasts develop phenotypic characteristics of …
-
THE IMPACT OF ACROLEIN ON LUNG FUNCTION: EXPLORATION OF NITROSATIVE STRESS-INDUCED LUNG INJURY AND THERAPEUTIC APPROACHES
… nebulization to understand the dynamic airway responsiveness as well as Negative Pressure Forced Expiration (NPFE) to determine the static airway properties to determine lung compliance. In addition to using mechanical measurements of lung function, we used a few well-established assays …
-
Sex and gender in chronic obstructive pulmonary disease
… emphysema whereas female smokers would have more airway wall remodeling using data from high resolution computed tomography (HRCT) scans. We did detect more emphysema in male smokers but there was no evidence of increased airway remodeling in women. We discuss the limits of HRCT to detect airway …
-
Expanding Allergen-specific Tr-1 CD4+ T cells to treat Allergic Asthma
… secondary to an underlying dysfunction of the airway driven by immune-mediated inflammation. Our lab has been developing a nanoparticle based therapy to deliver antigen-specific peptide-major histocompatibility complex to treat autoimmunity, which triggers the induction and expansion of cognate …
-
Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
… may contribute to induction and progression of airway remodeling (AR) seen in the airways of asthmatic subjects. Thickening of the lamina reticularis is a component of AR that is due to increased deposition of matrix proteins by mesenchymal cells that are increased in asthmatic airways, although …
-
Implicación de igf1r en inflamación pulmonar aguda y en alergia inducida por ácaros del polvo doméstico en ratones
… in mice to evaluate the resolution of allergic airway inflammation. Results: Unchallenged eight-week-old CreERT2 male mice showed a significant reduction of Igf1r expression in all organs analyzed, reflected in delayed body growth and reduced size of testes. Testes revealed halted …
-
Fibroblasts as matrix modulating cells in asthma and COPD
… play a key role. This phenomenon is defined as airway remodeling and is characterized by a deposition of extracellular matrix (ECM) molecules such as collagens and proteoglycans. Importantly, hitherto available studies have only studied fibroblast from central airways from humans where the role …
-
Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… Allergic asthma is clinically characterized by airway hyperreactivity (AHR), increased mucus production and airway remodeling. On the cellular level, pulmonary eosinophilic infiltration and augmented levels of serum IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway …
-
Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… Allergic asthma is clinically characterized by airway hyperreactivity (AHR), increased mucus production and airway remodeling. On the cellular level, pulmonary eosinophilic infiltration and augmented levels of serum IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway …
-
Neurokinin-1 antagonism as a novel treatment for feline asthma : investigation of the role of substance p in airflow limitation and airway inflammation
… and/or episodic respiratory distress induced by airway hyperresponsiveness (AHR), airway eosinophilia, and airway remodeling. Homeostasis in the lung is partially maintained by the neuroimmune axis, where cross-talk between these systems is mediated via cytokines, neuropeptides and their …
-
Chloride Channel 3 (CLC3), an Immune Antiporter in the Migration and Activation of Human Eosinophils in Allergic Asthma
… is a complex and heterogeneous disease of the airways. Eosinophils migrate to the airways under the influence of chemokines to start an excessive damage and repair cycle leading to airway inflammation and remodeling in allergic asthma. TGF-β has been closely related with eosinophils in airway …
-
Regulation of airway epithelial cell migration by the cystic fibrosis transmembrane conductance regulator.
The airway epithelium is a critical barrier between the noxious particles in inspired air and the lung tissue. Mucociliary clearance is an essential function of the airway epithelium to protect against infection and airway damage. By this process, inhaled particles are trapped in the mucus lining …
-
Investigation of the proteins SPARC and HMGB1 in chronic airways disease
… growth factor-beta (TGF-β), a key driver of airway remodeling in chronic airways disease, and demonstrates context-dependent immunoregulatory functions. Although airway inflammation and remodeling are prominent features of asthma and chronic obstructive pulmonary disease (COPD), the role of …
Page 1 of 2