Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 573 for “"Airway"”.
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A microfluidic mucosal airway model to study airway mucosal function and pathogenesis
Airway mucus hypersecretion or impaired clearance is one of the key pathophysiological features of airborne infection, allergy and severe respiratory diseases. As foreign particles enter the lungs, the airway becomes inflamed and excessive amount of mucus is generated in response. However, little …
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Nitric oxide in airway inflammation
… (EBC) is a non-invasive method of investigating airway inflammation associated with nitric oxide (NO) and the metabolites nitrite/nitrates (NOx) in diseases such as chronic obstructive pulmonary disease (COPD), but some of the variables affecting the results are unknown. It was hypothesised that …
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Decellularized Cartilage for Airway Repair
… reconstruction (LTR) to enlarge the airway by implanting autologous cartilage from a rib graft. However, young children often lack sufficiently sized costal cartilage for this procedure, resulting in increased donor site morbidity and operative time, as well as an elevated risk for …
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Development of Simulation Platform for Oropharyngeal Airway Placement and Design Evaluation of the Bardo Airway
<p>Off-label use of traditional Oropharyngeal Airway (OPA) as a bite-block, and the subsequential procedure of force exertion of the device by physician has caused many cases of patient’s teeth damage and monetary loss, as the patient’s incisors were damaged while clenching on the OPA during an …
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Comparison of Airway Response in Recurrent Airway Obstruction-Affected Horses Fed Steamed Versus Non-steamed Hay
Recurrent Airway Obstruction (RAO)-affected horses experience bronchoconstriction and airway inflammation in response to inhalation of irritants including hay molds. Steaming hay reduces fungal content, but the effect on the antigenic potential has not been investigated. We tested the hypothesis …
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Packaging and Secretion of Airway Mucins
<p>In the conducting airways of the lungs, the mobile mucus gel layer sits on top of the airway epithelium, and through ciliary beating it is propelled up the trachea into the pharynx where it is swallowed and cleared. This gel layer is composed of secreted mucins that become hydrated once reaching …
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Computational modeling of asthmatic airway collapse
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1998.
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Essays on airport and airway congestion
Runway and airspace congestion are the primary causes of flight delays in the US. These delays cost airlines and airline customers billions of dollars per year. This thesis consists of two essays. The first essay focuses on several of the commonly proposed market-based solutions to airport …
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Perturbed equilibria of myosin binding in airway smooth muscle and its implications in airway hyperresponsiveness and asthma
In asthma, the key effector driving acute airway narrowing is thought to be airway smooth muscle (ASM); as the muscle surrounding the airways shortens, the airway lumen narrows. Airway hyperresponsiveness (AHR) - the excessive narrowing of the airways - is one of the cardinal features of asthma. …
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Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.
… asthma, a chronic inflammatory disease of the airways, show pathological changes in the airways, including airway remodeling, basement membrane thickening, and epithelial damage with large immune cell infiltrate. How the epithelium contributes to airway remodeling and subepithelial fibrosis is …
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Exhaled nitric oxide in asthmatic airway inflammation
… (eNO) in the breath is a new method to monitor airway inflammation in asthma and may have a role in the management of asthma. The hypotheses were that eNO will reflect the degree of inflammation in chronic asthma, and will indicate how anti- inflammatory therapy should be altered to improve …
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Feasibility of Individualized Airway Surgery in Horses
… models in the investigation of multiple upper airway surgeries for recurrent laryngeal neuropathy (RLN) in horses. Overall, the objective was to build the knowledge of laryngeal conformation and fluid mechanics with various surgical procedures for application in patients as an evaluation for …
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ATP, TRP channels and airway neuronal sensitisation
Cough is a productive reflex controlled by airway nerves which is respiratory conditions such as chronic obstructive pulmonary disease (COPD), becomes hyperresponsive contributing to the clinical problem of chronic cough. This project was focused on gaining a deeper understanding of the roles of …
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Endogenous atrial natriuretic factor and airway control
… natriuretic factor (ANF) in the modulation of airway calibre and bronchial hyperresponsiveness in humans under normal physiological conditions. Two approaches are used. One approach examines the diurnal variation of endogenous ANF and its effect on the airway function of asthmatics and …
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… and OBJECTIVE: Leukotriene E4 contributes to airway inflammation by interacting with P2Y12 receptor as well as type 1 and 2 cysteinyl leukotriene receptors. We investigated the effects of P113, a P2Y12 receptor antagonist, on airway inflammation in a mouse model of allergic asthma. MATERIALS …
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