Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Air Liquid Interface (ALI)"”.
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The development of novel strategies to modulate epithelial sodium channel (ENaC) activity in chronic obstructive pulmonary disease (COPD)
Impaired mucociliary clearance (MCC) which leads to infection, inflammation, and progressive lung damage is a hallmark of the chronic bronchitis (CB) phenotype in COPD, and the hydration status of the airways has been indicated as the main factor affecting this disorder. Inhibition of ENaC function …
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Elucidating Astrocytic Diversity in Human Cerebral Organoids
… in human cortical organoids grown at the air-liquid interface (ALI-COs) for up to 495 days in vitro (DIV). It shows that ALI-CO development displays considerable similarities with the human fetal cortex and undergoes significant gliogenesis at 200DIV. In particular, two novel astrocytic …
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Investigating the impact of e-cigarettes on lung cells: a combined in vitro and computational study
… while MTL led to greater deposition in the upper airways. These differences reflected DTL’s higher flow rates and larger puff volumes. Deposited particle mass ranged from 1×10−7 to 4×10−3 mg, highlighting the importance of dose targeting based on lung region. To investigate the effects of EC …
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Maturation of pluripotent stem cell-derived alveolar type II cells at air-liquid interface and response to environmental stimuli
… during expiration. AT2s exist at a physiological interface between inhaled air and pulmonary vasculature, and are among the pulmonary cell types that are directly exposed to inhaled environmental stimuli such as respiratory viruses and cigarette smoke. Primary human AT2s can be cultured in vitro …
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INVESTING THE ROLES OF E26 TRANSFORMATION-SPECIFIC HOMOLOGOUS FACTOR IN CYSTIC FIBROSIS LUNG DISEASE
… conductance Regulator (CFTR), is impaired, dehydrating all epithelia. The principal cause of morbimortality of CF is CF lung disease (CFLD) where CF airways have impaired mucociliary clearance and undergo constant remodelling and chronic inflammation, ultimately leading to …
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Mechanisms of virus infection of human airway epithelium cultured at an air-liquid interface (HAE-ALI)
ABSTRACT Polarized human airway epithelial (HAE) cultures are instrumental for studying respiratory tract diseases and gene delivery of airways. Primary epithelial cells isolated from tracheobronchial airways, grown in transwell at an air-liquid interface (ALI), undergo media-induced mucociliary …
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Developing bioelectronic sensors for 3D in vitro models at the air liquid interface: Innovative technology for biomedical and respiratory research.
Respiratory diseases and airborne infections are significant global health issues and a major cause of morbidity and mortality worldwide. According to the World Health Organization (WHO), respiratory diseases rank as the third leading cause of death globally, with over 10 million deaths per year …
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Strategies to Target the Bone Morphogenetic Protein Signalling Pathway in Lung Disease
… delivery of different of more toxic drugs to the airways in order to increase efficiency of both the delivery mechanism and of the drug utilised. Here we looked at the use of a number of different mechanisms, which can be used as stand-alone devices/delivery agents and/or in conjunction with other …
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Tissue engineering of a tracheal substitute
… the presence of ciliated cells thereby validating the UEA positive staining. The presence of both established and developing cilia was also verified. This indicates that collagen biomaterials are appropriate for the tissue engineering of REC. Furthermore, that UEA and PNA staining is a …
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L'applicazione delle metodologie del nuovo approccio in vitro per chiarire i meccanismi di potenziale tossicità dell'EVP e delle sigarette combustibili
… di consumare nicotina attraverso metodi tradizionali (ad esempio il fumo di sigaretta), incoraggiando la loro sostituzione con altri prodotti contenenti nicotina che potenzialmente comportano minori rischi [13]. "Clearing the Smoke" è stato il primo riconoscimento ufficiale che la nicotina può …