Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Agrin"”.
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Die Wirkung von Agrin auf die Genexpression isolierter Maus-Podozyten in Langzeitkultur
… Arbeit befasst sich mit der Rolle von Agrin am Glomerulus. Am Glomerulus wird das Heparansulfat-Proteoglykan Agrin von Podozyten synthetisiert und daraufhin in die glomeruläre Basalmembran integriert. Als Strukturprotein hilft es, die Podozyten über a-Dystroglycan in der glomerulären …
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Structural and Functional Aspects of Dystroglycan During Agrin -Mediated Acetylcholine Receptor Clustering at the Mammalian Neuromuscular Junction
… on dystroglycan support dystroglycan as an agrin-binding protein. More specifically, data suggests that the carbohydrate residues on dystroglycan may be involved in binding to agrin. However, genetic and functional studies on dystroglycan's role in agrin-mediated acetylcholine receptor …
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DEVELOPMENT OF A TISSUE ENGINEERED SKELETAL MUSCLE REPAIR CONSTRUCT FEATURING BIOMIMETIC PHYSICAL, CHEMICAL, AND MECHANICAL CUES
… fibrin biomaterial and treated with neural (Z+) agrin exhibited clusters of acetylcholine receptors (AChRs). When agrin was presented bound to the surface of a carrier microparticle, this response was spatially restricted to areas of cell – microparticle contact. Moreover, AChR clusters were …
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The effect of whey protein-polyphenol on the recovery of muscle function and strength following eccentric exercise- the myogenic and neural contributions to eccentric exercise.
… with protein-pomegranate supplementation. Plasma agrin concentration, a proxy measure of NMJ function and integral to NMJ stability and integrity, in part via acetylcholine receptor clustering, also declined at 24h but did not differ between groups. In the subsequent study (Chapter 5), conducted …
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Neuroprotective Effects of FGF20 on Dopamine Neurones
… have shown the heparin sulphate proteoglycan, agrin to potentiate FGF2 stimulated ERK1/2 activation and neurite outgrowth in PC12 cells. It was demonstrated here that agrin potentiates FGF20 stimulated ERK1/2 activation, but it fails to potentiate FGF20’s neuroprotective effects in PC12 cells.
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Die Rolle von transformierenden Wachstumsfaktoren-beta (TGF-β) in der Entwicklung von Synapsen
… dass diese Reduzierung durch einen Verlust an Agrin-stabilisierten Azetylcholin-Rezeptor-Clustern verursacht sein könnte. Dies führte zu der Hypothese, dass TGF-β2 an der neuromuskulären Endplatte als Ko-Faktor für Agrin die Nerv-Muskel-Interaktion modulieren könnte. Die TGF β2-defizienten …
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Nephrotic Syndrome and Glomerular Basement Membrane: Genetic Defect of the Laminin α5 Chain
… a reduced secretion, integrin β1 activation, and agrin expression ultimately resulting in possible instability of the podocyte actin cytoskeleton.
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Neuromuscular Synaptic Proteins In Development And Regeneration
… example, neuromuscular synapses form through the Agrin-Lrp4-MuSK signaling pathway that clusters acetylcholine receptors beneath motor axon terminals, yet in vivo role of this pathway in peripheral nerve regeneration has not been examined. To determine whether this pathway is employed during …
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Mechanisms of Type IV Collagen Targeting to Developing Basement Membranes
… the roles of the matricellular proteins nidogen, agrin, perlecan, and SPARC in the targeting of collagen to pharyngeal and gonadal BMs. In Chapter 4, I identify potentially novel regulators of type IV collagen incorporation into BMs through a genome-scale RNAi screen. Finally, in Chapter 5, I …
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Tissue Engineering von Skelettmuskelgewebe : neue Ansätze zur Generierung von Skelettmuskelgewebe in vitro und in vivo
… untersuchte Expression von neuronalem Agrin, der Triadin-Isoform Trisk51 und der epsilon-Untereinheit des reifen Azetylcholinrezeptors belegten die Differenzierunginduktion durch das neuronale Gewebe. <br>Als alternativer Ansatz zur Differenzierungsinduktion wurde ein eukaryoter …