Global ETD Search
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Showing 1 to 5 of 5 for “"AgrC"”.
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Mechanism of Signal Transduction By The Staphylococcus Aureus Quorum Sensing Receptor AGRC
… peptide (AIP) pheromone activates the AgrC receptor histidine kinase, resulting in downstream modulation of virulence factor expression. As S. aureus is a dangerous pathogen, understanding virulence regulation is of great interest, and the agr system has been extensively studied. …
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Reconstitution and Mechanistic Studies on the Staphylococcal agr Quorum Sensing Circuit
… the AIP-sensing receptor histidine kinase (HK), AgrC, whose auto-phosphorylation exhibits several remarkable properties in our reconstitution system based on nanometer-scale lipid-bilayer discs (nanodiscs). Activation of this receptor by its native activator, for instance, requires a membrane …
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Studies on the Maturation of Secreted Quorum Sensing Peptides That Regulates S. Aureus Virulence
… (AIPs) and detection of their concentration via AgrC, a transmembrane receptor histidine kinase, coordinates local bacterial population density with global changes in gene expression. In order for S. aureus to produce AIP, three proteolytic transformations involving the proteins AgrB and SpsB are …
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Targeting Receptor-Histidine Kinase Signaling in Staphylococcus Aureus
… studies on the receptor-histidine kinase, AgrC, have demonstrated that intra-group activation and inter-group inhibition are both mediated by the same group-specific receptors. Pharmacological analysis has shown that the AIPs compete for a common binding site on the receptor, and this site …
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ST-1 VISA/DAP-R CA-MRSA INTEGRATED OMICS: A FIRST REPORT OF HYPER-VIRULENCE AND MULTI-DRUG RESISTANT SUPERBUG
… impact in the protein effectiveness (e.g. AgrC, ClfA, ClfB, DnaJ, IcaB, MprF, MurC, MurE, RpoB, SdrD, SodA, SodM). Most of the amino-acid alterations described in this work have not previously been associated with the VISA/DAP-R phenotype, except for T345A in mprF and H481Y in rpoB related …