Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Agmatine"”.
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The Impact Of The Inhibitory Neuromodulator Agmatine On Microglia Function In The Contexts Of Pain And Addiction
… the evaluation of mechanistic properties of agmatine, an inhibitory neuromodulator in therapeutic development for chronic pain and opioid use disorder.
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Characterization and regulation of the speA gene in Escherichia coli
… biosynthetic pathway. ADC converts arginine to agmatine, which is hydrolyzed by agmatine ureohydrolase, encoded by the speB gene, to putrescine and urea. ADC is negatively regulated by mechanisms requiring either cAMP and cAMP receptor protein (CRP) or putrescine. A 3,236 base pair (bp) …
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Characterization of structure, function and regulation of the speB gene in Escherichia coli
The speB gene of E. coli encodes agmatine ureohydrolase (AUH). AUH catalyses the hydrolysis of agmatine to urea and putrescine in a polyamine biosynthetic pathway. The plasmid pKA5, derived from an E. coli genomic library, was the source of a 2.97 kb restriction fragment containing the speB gene. …
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Utility of Ion Mobility – Mass Spectrometry in Peptidoglycan Structural Determination
… The PG of L. platensis was found to contain agmatine as a modification to the D-iso-glutamic acid residue within the peptide stem. This modification was found to exist within most (~90 %) of its identified muropeptides, indicating that agmatine may play an important role in L. platensis …
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Kinetic, Mechanistic, and Inhibition Studies On the Deiminase Family of Enzymes
<p>Protein arginine deiminase (PAD) and agmatine deiminase (AgD) both belong to the guanidino-group modifying enzymes superfamily. Although these two enzymes catalyze a similar reaction, the conversion of a guanidinium to a ureido and ammonia, their substrates differ greatly, i.e., …
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ANTIFUNGAL ACTIVITY OF NATURAL AND NATURAL-INSPIRED BIOACTIVE COMPOUNDS TO CONTROL THE RICE BLAST FUNGUS
… siderophores (16a), phenylamides (feruloyl-agmatine 3f, feruloyl-tyramine 3b), and phlorotannins (15)—demonstrated their capacity to impair spore germination, appressorium formation, and fungal infection. Confocal microscopy revealed that feruloyl-agmatine 3f partially inhibited …
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Retinal development and age related degeneration following gestational lead exposure
… immunohistochemistry, confocal microscopy, agmatine probe labeling, and pharmacological assays. RESULTS: GLE decreased the relative expression of rod specific genes at PN2; delayed the differentiation and functional development of rod photoreceptors and bipolar cells by 2-3 days; increased …
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The potential antioxidant and anticancer properties of polyamines and their response to high-intensity ultrasonication
… spermine, putrescine, and spermidine. Agmatine showed no antioxidant capacity. Spermine and spermidine inhibited the growth of 4T1 cells at IC50 of 6.0 µg/mL and 21.5 µg/mL, respectively. No anti-carcinogenic effects were observed in this cell system with putrescine. Abiotic stress …
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In vivo and in vitro aspects of imidazoline-2(1/2)sites within the central nervous system
… drug discrimination. Further studies indicated agmatine, a proposed endogenous imidazoline ligand, and a number of imidazoline and imidazole analogues of 2-BFI substitute significantly for 2-BFI. In addition to specific I2 ligands the administration of NRl's (noradrenaline reuptake inhibitors), …
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Identificación taxonómica y clonal de bacterias acéticas, y estudio del efecto de la nisina frente a biofilms de bacterias enológicas
… but it did not generate any biogenic amine (agmatine, spermidine, phenylethylamine, histamine, or putrescine) either in presence or in absence of ethanol in the culture broth. These results indicate that nisin preparations with the appropriate concentrations could inhibit undesired LAB and …
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Development of Improved Genetic Methods for Enterococcus Faecium
… integrated inducible dCas9 controlled by IPTG or agmatine inducible systems in VREfm. Furthermore, I generate and characterize a compact, highly transformable single-guide RNA (sgRNA) delivery vector for CRISPRi assays. In developing CRISPRi for VREfm, I discover a putative anti-CRISPR protein …
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Isolation and characterization of African marine natural products and repositioning of the natural product antibiotic fusidic acid and privileged benzimidazole scaffold for tuberculosis and malaria
… and valine, and the small alkaloids, choline and agmatine. The natural product antibiotic, fusidic acid, has been in clinical use as, largely, a bacteriostatic agent against staphylococcal pathogens since 1962. Having exhibited a similar mode of action via inhibition of Mycobacteria tuberculosis …