Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Aggressive Phenotypes"”.
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Nherf1 – New Modifier of Colorectal Cancer Progression
… restore the epithelial phenotype but led to more aggressive phenotypes. Our findings suggest that membrane NHERF1 is an important regulator of epithelial morphogenesis, and that changes in NHERF1 expression correlate with CRC progression. NHERF1 loss and ectopic expression that induce massive …
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THE EFFECTS OF ACIDOSIS ON SURVIVAL PATHWAYS IN LYMPHOID MALIGNANCIES
… Importantly, tumor acidity correlates with aggressive phenotypes and resistance to therapy. Yet, the basis for these observations remains poorly understood. Herein we report that acidosis promotes the inappropriate survival of cancer cells through regulation of several apoptosis-governing …
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Development of small-molecule probes for photoacoustic imaging of hypoxia
… in gene expression lead to treatment resistance, aggressive phenotypes, and increased metastatic potential; thus, imaging tumor hypoxia has important implications in treatment planning and predicting patient prognosis. Herein we discuss our approach for hypoxia detection using photoacoustic (PA) …
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… (PDAC) is recognised as an exceptionally aggressive form of cancer, notorious for its limited treatment options, resistance to chemotherapy, and consequent poor prognosis. This dissertation comprehensively explores the potential of targeting the urokinase plasminogen activator (uPA) …
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Evaluation of new PET tracers for receptor tumour imaging
… being overexpressed in range of cancers with aggressive phenotypes. Therefore, it is of high interest to develop non-invasive methods to identify tumour sites with higher CXCR4 expression levels and identify the likelihood of disease progression. The goal of this work was to characterise a …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… Higher AR and AR-SV expression and corresponding aggressive phenotypes were observed predominantly in specimens obtained from African American women. RNA sequencing of LAR TNBC specimens indicates an enrichment of hallmark interferon, JAK/STAT, and androgen signaling pathways, which were exclusive …
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Characterizing and analyzing disease-related omics data using network modeling approaches
… interact with each other to produce biological phenotypes. A number of tools for comprehensive and high-throughput measurements of DNA/RNA, protein and metabolites have been developed. Each of these technologies helps to characterize individual components of the genome, proteome or metabolome …
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The anticipatory unfolded protein response and estrogen receptor mutations in breast cancer
… wild-type ERα. To better characterized the aggressive phenotypes of the ERα mutations in breast cancer cells, we used CRISPR-Cas9 technology to replace wild-type ERα in T47D, human breast cancer cells, with the most common mutations, ERαY537S and ERαD538G. The mutant cells exhibit partially …
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NEW INSIGHTS INTO PATHOGENESIS AND PROGNOSIS OF CANINE SARCOMAS
… may be potential therapeutic targets for more aggressive phenotypes of these tumors. Finally, the study confirmed the prognostic role of mitotic count and tumor size in cPWTs. The third study focused on canine STSs surgical margin assessment investigating the impact of clean but close margins …
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Delivery of Myoglobin Polymersomes Results in Tumor Hemorrhagic Necrosis and Enhanced Radiation Response
… with hypoxic tumors have worse prognosis due to aggressive phenotypes and resistance to radiotherapy and chemotherapy. The overall goal of this work is to improve response to conventional cancer therapies by targeting tumor hypoxia. This has been carried out and evaluated through the use of …