Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Aggressive Breast Cancer"”.
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
<p>Triple-negative breast cancer (TNBC) and inflammatory breast cancer (IBC) are the most aggressive breast cancer subtypes. The tumor microenvironment (TME) is critical in driving these aggressive breast cancers' clinical phenotype and aggressiveness. Therefore, we explored novel actionable …
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Evaluating Phosphatidylinositide as Lipid Biomarkers for Hyperglycemia-related Triple-negative Breast Cancer Aggressiveness
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, marked by limited treatment options and poor patient outcomes. Clinical and epidemiological studies suggest that systemic metabolic conditions, particularly high blood glucose associated with Type 2 Diabetes, may …
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The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer
<p>Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis and is difficult to treat. A diagnosis of TNBC means that the three most common types of receptors known to fuel most breast cancer growth–estrogen, progesterone, and HER2– are not present in the …
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Disparities in breast cancer subtype, staging, and access to mammography services in the Lower Mississippi Delta Region
… the country as a whole. It also has far higher breast cancer mortality rates than the nation. Black women in the Region have higher breast cancer mortality rates than white women in the Delta Region and have higher breast cancer mortality rates than black women in other parts of the country. …
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Caffeine Binding Non-Canonical Biased Adenosine A₂AR GPCR Modulates Neu1 Activation and Signaling in Breast Cancer Cells
… receptor signaling networks contribute to breast cancer progression and metastatic plasticity, particularly in triple-negative breast cancer (TNBC), an aggressive subtype with limited therapeutic options. Among these signaling systems, the adenosine A₂A receptor (A₂AR), a G protein‑coupled …
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MULTI-OMIC LINEAGE TRACING PREDICTS THE MOLECULAR DRIVERS OF CANCER STEM CELLS IN TRIPLENEGATIVE BREAST CANCER EVOLUTION.
Triple-Negative Breast Cancer (TNBC) is the most aggressive breast cancer subtype, and patients still rely primarily on chemo-neoadjuvant therapy (NACT). Their poor prognosis is largely driven by extensive phenotypic heterogeneity, sustained by complex genetic and epigenetic interactions that are …
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The Role of Inflammation and Nitric Oxide Synthase 2 in Triple-Negative Breast Cancer Metastasis
… chemotherapeutic resistance in triple-negative breast cancer (TNBC) patients. The tumor microenvironment (TME) comprises various cell types that play a role in tumor survival and invasion by providing soluble factors such as pro-inflammatory cytokines IFN-γ, IL-1β, and TNF-α, which are known to …
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Investigation of S1P and S1P Signaling in Adipocytes and Adipocyte-Breast Cancer Cell Interaction
Breast cancer continues to be the most commonly occurring cancer in women worldwide, with triple-negative breast cancer (TNBC) as the most aggressive subtype with a high risk of metastasis and recurrence. Obesity is one of the factors that increase breast cancer risk and progression, and high …
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A Screen For Peptides Targeting Chemoresistant Metastatic Triple-Negative Breast Cancer
<p>Cancer metastasis is the principal cause of most cancer-associated morbidities. While radiotherapy, hormone therapy, and novel therapeutic strategies, including immunotherapy, have shown promise in inhibiting tumor growth, chemotherapy remains the mainstay in the clinical management of …
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Life Style, Molecular Pathology, and Breast Cancer Risk
The breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. A major aim of this …
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Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
Breast cancer is one of the deadliest malignancies worldwide and also in the United States. Patients with triple negative breast cancer (TNBC), where the cancer cells do not express nuclear hormone receptors and human epidermal growth factor receptor 2 (HER2), have worse survival rate compared to …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
<p>Inflammatory breast cancer (IBC) and triple-negative breast cancer (TNBC) are two highly aggressive breast cancer subtypes associated with a poor outcome. Despite sensitivity to current treatment, these breast cancers subtypes have a high recurrence rate and proclivity to metastasize early. The …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
<p>Inflammatory breast cancer (IBC) and triple-negative breast cancer (TNBC) are two highly aggressive breast cancer subtypes associated with a poor outcome. Despite sensitivity to current treatment, these breast cancers subtypes have a high recurrence rate and proclivity to metastasize early. The …
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Role of long non-coding RNAs in breast cancer progression
Breast cancer is the most common cancer in women worldwide. The molecular mechanisms underlying the disease have been extensively studied, leading to dramatic improvements in diagnostic and prognostic approaches. Despite the overall improvements in survival rate, numerous cases of death by breast …
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Tracking Treatment Response and Resistance to Parp Inhibition (Talazoparib) In Hereditary Pancreatic Cancer.
… the treatment of <em>BRCA</em>-mutant ovarian cancer. In the phase III POLO (Pancreas cancer OLaparib Ongoing) trial presented at the American Society for Clinical Oncology (ASCO) conference in 2019, maintenance therapy with Olaparib significantly delayed the progression of metastatic …
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Mechanisms of Metastatic Spread of Breast Cancer to the Brain
Breast cancer is the most common cancer in females. Triple-negative breast cancer (TNBC), in which the tumour cells lack estrogen and progesterone receptors, and the HER2 protein, accounts for approximately 15% of all breast cancers and tends to have a younger onset and higher metastasis risk …
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Reporte de Caso. Rabdomiosarcoma Alveolar en mama como tumor primario
Introducción El rabdomiosarcoma alveolar (RMS) como tumor primario de mama, es una tipo de cáncer con una alta morbimortalidad a nivel mundial. Se describe la fisiopatología, evolución clínica y tratamiento de un caso de Rabdomiosarcoma alveolar como tumor primario de la mama en un paciente del …