Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Aggregation prone proteins"”.
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Insights into the structure and aggregation of lens crystallins and other aggregation-prone proteins
… The destabilization, partial unfolding, and aggregation of lens crystallin proteins cause the loss of lens transparency (opacification) and cataract formation. Numerous congenital mutations and age-related changes to the long-lived alpha-, beta- and gamma-crystallins are associated with …
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Insights into the structure and aggregation of lens crystallins and other aggregation-prone proteins
… The destabilization, partial unfolding, and aggregation of lens crystallin proteins cause the loss of lens transparency (opacification) and cataract formation. Numerous congenital mutations and age-related changes to the long-lived alpha-, beta- and gamma-crystallins are associated with …
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Investigating the protein disaggregation machinery in the early secretory pathway
Protein misfolding and subsequent aggregation represent key pathological features in various forms of dementia, notably Alzheimer’s disease (AD). AD is characterised by the presence of extracellular plaques, comprised of aggregated amyloid beta (Aβ) peptides, and intracellular neurofibrillary …
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Autophagy gridlock in tauopathy
… associated protein tau. Bulk degradation of aggregation-prone proteins can occur via autophagy. Here, we utilized the previously developed model of human tauopathy in Drosophila to examine how autophagy modulates human tau toxicity and to study the effects of human tau on the autophagic …
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Amyloid β Aggregation is Coupled to Cellular Metabolism and Intramitochondrial Proteostasis
… disorders characterised by peptide aggregation, such as Alzheimer's disease (AD), become more prevalent. Research efforts have aimed to unveil the underlying mechanism of disease pathogenesis in order to develop potential therapies. In particular, reports have focused on studying the …
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Kinetics of Disordered Proteins and their Interactions
Disordered proteins and regions are highly prevalent in the human proteome, and are often implicated in disease. However, methods to study these systems in detail are lacking, and the potential for thermodynamic and kinetic characterisation using experimental methods is limited. Molecular …
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Regulation of autophagosome formation and maturation by neurodegeneration-associated proteins
… or damaged cellular components, including the aggregation-prone proteins and dysfunctional organelles associated with neurodegenerative diseases. Autophagy cargoes are captured into double-membraned autophagosomes, which form as outgrowths from the Ras-related protein 11A (RAB11A)-positive …
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION
… be particularly vulnerable to toxic stress from aggregation-prone proteins such as α-synuclein. Induction of heat-shock proteins (HSPs), such as through activated heat shock transcription factor 1 (HSF1) via Hsp90 inhibition, is being investigated as a therapeutic option for proteinopathic …
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Biophysical Characterization of the ALS-Linked Protein TDP-43; and Genetic and Small Molecule Rescues from Its Cytotoxicity
… acids (mRNA) in human cells but is also aggregation prone and has been implicated in amyotrophic lateral sclerosis (ALS). The structure of this multi-domain protein remains unknown, as each domain is linked by a disordered linker region. The C-terminal domain (CTD) is largely disordered, …